Linked Life Data

3447247

Source:http://linkedlifedata.com/resource/pubmed/id/3447247

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
2
pubmed:dateCreated
1988-5-26
pubmed:abstractText
The renal clearances (C) of p-aminohippurate (PAH) and tetraethylammonium (TEA) as markers for renal plasma flow (RPF) were compared in rats under different experimental conditions. CTEA and CPAH were of the same magnitude and varied synchronously during volume expansion and anesthesia. The renal extractions of the two substances were closely correlated and averaged 85.9% for PAH and 88.7% for TEA (p less than 0.01). High doses of furosemide (120 mg/kg as intravenous bolus) reversibly decreased the CPAH/CTEA ratio, suggesting that furosemide may compete for PAH secretion in the proximal tubule. A similar effect was observed after administration of probenecid. The results indicate that TEA is a more reliable indicator of RPF than PAH in studies involving accumulation of endogenous or exogenous organic anions.
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:issn
0378-5858
pubmed:author
pubmed:issnType
Print
pubmed:volume
10
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
102-9
pubmed:dateRevised
2006-11-15
pubmed:meshHeading
pubmed:year
1987
pubmed:articleTitle
Superiority of tetraethylammonium to p-aminohippurate as a marker for renal plasma flow during furosemide diuresis.
pubmed:affiliation
Department of Pharmacology, University of Copenhagen, Denmark.
pubmed:publicationType
Journal Article, Research Support, Non-U.S. Gov't