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| Predicate | Object |
|---|---|
| rdf:type | |
| lifeskim:mentions | |
| pubmed:issue |
8
|
| pubmed:dateCreated |
1988-3-3
|
| pubmed:abstractText |
The stability of sulphamethoxydiazine (1) in HCl (1 mol/l) under elevated temperature was investigated. Isolated decomposition products further served as standards for the selection of HPLC conditions. Three types of stationary phases were tested: Pragosil 5, MicroPak CN-10, MicroPak CH-10. The selection of mobile phases was made in such a way as to be able to inject 1 hydrolysate in HCl (1 mol/l) directly or after simple dilution. Detection was performed with an UV detector at the wavelength of 226 nm. A column packed with MicroPak CN-10 was selected to investigate the process of 1 decomposition. The method made it possible to quantify 1 in the course of hydrolysis and to illustrate the process of decomposition. On the basis of continuous examination of the development of decomposition products during the stability study it was possible to consider the chemism of the decomposition reaction.
|
| pubmed:language |
ger
|
| pubmed:journal | |
| pubmed:citationSubset |
IM
|
| pubmed:chemical | |
| pubmed:status |
MEDLINE
|
| pubmed:month |
Aug
|
| pubmed:issn |
0031-7144
|
| pubmed:author | |
| pubmed:issnType |
Print
|
| pubmed:volume |
42
|
| pubmed:owner |
NLM
|
| pubmed:authorsComplete |
Y
|
| pubmed:pagination |
511-3
|
| pubmed:dateRevised |
2007-1-29
|
| pubmed:meshHeading | |
| pubmed:year |
1987
|
| pubmed:articleTitle |
[The use of high pressure liquid chromatography in stability studies of sulfonamides. 3. Sulfamethoxydiazine. Isolation and identification of hydrolytic decomposition products].
|
| pubmed:affiliation |
Lehrstuhl für pharmazeutische Chemie, Pharmazeutische Fakultät der Karls-Universität, Hradec Kralové, CSSR.
|
| pubmed:publicationType |
Journal Article,
English Abstract
|