Linked Life Data

3431658

Source:http://linkedlifedata.com/resource/pubmed/id/3431658

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
5
pubmed:dateCreated
1988-2-26
pubmed:abstractText
Modulation of CA1 electrophysiological properties (amplitude, latency, paired-pulse facilitation) by different concentrations of corticosterone (CT) was studied in hippocampal slice preparations from normal (sham) and adrenalectomized (ADX) BALB/c mice. In the sham group, CT effects on the population spike (PS) amplitude were biphasic: at a low dose (200 pM) CT induced a delayed increase; at a moderate dose (2,000 pM), a rapid and partially reversible decrease was observed, and at higher doses (5,000 and 10,000 pM) this decrease was more pronounced after 30 min of washout. Diminution of latency and paired-pulse facilitation were obtained for the CT concentration inducing an increase of the PS amplitude. In the ADX group, similar CT effects were observed for lower doses: a decrease of the PS amplitude was observed for 40 and 100 pM and an increase for 5 pM, but variations of the PS amplitude were weaker than in the sham group. The role of the different CT receptor systems in this neuromodulatory effect is discussed.
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:month
Nov
pubmed:issn
0028-3835
pubmed:author
pubmed:issnType
Print
pubmed:volume
46
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
424-9
pubmed:dateRevised
2006-11-15
pubmed:meshHeading
pubmed:year
1987
pubmed:articleTitle
Effects of corticosterone on hippocampal slice electrophysiology in normal and adrenalectomized BALB/c mice.
pubmed:affiliation
Department of Behavioral Neurobiology, UA CNRS 372, University of Provence, Marseilles, France.
pubmed:publicationType
Journal Article, Comparative Study, In Vitro