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rdf:type |
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lifeskim:mentions |
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pubmed:issue |
4
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pubmed:dateCreated |
1988-3-21
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pubmed:abstractText |
Deletions in chromosome 7 of the mouse affect the expression of the metallothionein gene Mt-1, which maps on chromosome 8, and steady-state levels of Mt-1 mRNA are reduced to 15-40% of normal in livers of newborn mice homozygous for either the c3H or c14CoS deletion. Glucocorticoids fail to induce hepatic Mt-1 mRNA levels in deletion homozygotes in contrast to normal littermates. However, zinc chloride is effective in inducing Mt-1 mRNA levels in livers of deletion homozygotes as well as of their normal littermates. Other tissues (e.g., kidney and intestine) of deletion homozygotes express basal levels of Mt-1 mRNA higher than those of normal littermates. In the intestine these are furthermore inducible by both hormonal and metal agents. Thus, loss of inducibility of the Mt-1 gene in deletion homozygotes concerns glucocorticoids only and is furthermore restricted to specific cell types (i.e., hepatocytes). The trans-acting factor(s) normally encoded in the deleted region of chromosome 7 appears to be instrumental in conferring on the metallothionein gene in hepatocytes the essential competence to respond to hormonal inducing signals.
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pubmed:grant |
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pubmed:commentsCorrections |
http://linkedlifedata.com/resource/pubmed/commentcorrection/3422486-2421601,
http://linkedlifedata.com/resource/pubmed/commentcorrection/3422486-2439393,
http://linkedlifedata.com/resource/pubmed/commentcorrection/3422486-2859594,
http://linkedlifedata.com/resource/pubmed/commentcorrection/3422486-2879499,
http://linkedlifedata.com/resource/pubmed/commentcorrection/3422486-2885194,
http://linkedlifedata.com/resource/pubmed/commentcorrection/3422486-3460089,
http://linkedlifedata.com/resource/pubmed/commentcorrection/3422486-3527054,
http://linkedlifedata.com/resource/pubmed/commentcorrection/3422486-36985,
http://linkedlifedata.com/resource/pubmed/commentcorrection/3422486-3785203,
http://linkedlifedata.com/resource/pubmed/commentcorrection/3422486-3792622,
http://linkedlifedata.com/resource/pubmed/commentcorrection/3422486-3857594,
http://linkedlifedata.com/resource/pubmed/commentcorrection/3422486-4146177,
http://linkedlifedata.com/resource/pubmed/commentcorrection/3422486-4858102,
http://linkedlifedata.com/resource/pubmed/commentcorrection/3422486-518835,
http://linkedlifedata.com/resource/pubmed/commentcorrection/3422486-6095054,
http://linkedlifedata.com/resource/pubmed/commentcorrection/3422486-6171301,
http://linkedlifedata.com/resource/pubmed/commentcorrection/3422486-6305566,
http://linkedlifedata.com/resource/pubmed/commentcorrection/3422486-6326095,
http://linkedlifedata.com/resource/pubmed/commentcorrection/3422486-6572398,
http://linkedlifedata.com/resource/pubmed/commentcorrection/3422486-6692472,
http://linkedlifedata.com/resource/pubmed/commentcorrection/3422486-6870774,
http://linkedlifedata.com/resource/pubmed/commentcorrection/3422486-6955027,
http://linkedlifedata.com/resource/pubmed/commentcorrection/3422486-7188777,
http://linkedlifedata.com/resource/pubmed/commentcorrection/3422486-7231555,
http://linkedlifedata.com/resource/pubmed/commentcorrection/3422486-7240167,
http://linkedlifedata.com/resource/pubmed/commentcorrection/3422486-911786
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
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pubmed:status |
MEDLINE
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pubmed:month |
Feb
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pubmed:issn |
0027-8424
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pubmed:author |
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pubmed:issnType |
Print
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pubmed:volume |
85
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
1161-4
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pubmed:dateRevised |
2009-11-18
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pubmed:meshHeading |
pubmed-meshheading:3422486-Albinism,
pubmed-meshheading:3422486-Animals,
pubmed-meshheading:3422486-Chlorides,
pubmed-meshheading:3422486-Chromosome Deletion,
pubmed-meshheading:3422486-Chromosome Mapping,
pubmed-meshheading:3422486-Dexamethasone,
pubmed-meshheading:3422486-Gene Expression Regulation,
pubmed-meshheading:3422486-Homozygote,
pubmed-meshheading:3422486-Intestines,
pubmed-meshheading:3422486-Kidney,
pubmed-meshheading:3422486-Liver,
pubmed-meshheading:3422486-Metallothionein,
pubmed-meshheading:3422486-Mice,
pubmed-meshheading:3422486-Mice, Mutant Strains,
pubmed-meshheading:3422486-RNA, Messenger,
pubmed-meshheading:3422486-Zinc,
pubmed-meshheading:3422486-Zinc Compounds
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pubmed:year |
1988
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pubmed:articleTitle |
Metallothionein mRNA expression in mice homozygous for chromosomal deletions around the albino locus.
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pubmed:affiliation |
Department of Biological Sciences, University of Pittsburgh, PA 15260.
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pubmed:publicationType |
Journal Article,
Research Support, U.S. Gov't, P.H.S.,
Research Support, Non-U.S. Gov't
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