|
rdf:type |
|
|
lifeskim:mentions |
|
|
pubmed:issue |
3
|
|
pubmed:dateCreated |
1988-3-11
|
|
pubmed:abstractText |
A sequence centered 166 nucleotides upstream of the mouse H-2Kb class I major histocompatibility gene binds a nuclear factor, H2TF1, found in many cell types. Previous studies have shown that binding of H2TF1 to this sequence stimulates class I gene expression. Furthermore, this factor binds a similar sequence in the 72-base-pair repeat enhancer element of simian virus 40. We show here that NF-kappa B, an inducible B-cell-specific factor that binds the kappa immunoglobulin light chain gene enhancer, also binds the H2TF1 regulatory sequence. Methylation-interference experiments demonstrate that NF-kappa B closely interacts with six of the eight symmetrically positioned guanines that contact H2TF1. These experiments suggest that NF-kappa B may play a role in class I major histocompatibility gene expression and that H2TF1 and NF-kappa B may be related DNA-binding proteins.
|
|
pubmed:grant |
|
|
pubmed:commentsCorrections |
http://linkedlifedata.com/resource/pubmed/commentcorrection/3422454-11894934,
http://linkedlifedata.com/resource/pubmed/commentcorrection/3422454-2879243,
http://linkedlifedata.com/resource/pubmed/commentcorrection/3422454-3031512,
http://linkedlifedata.com/resource/pubmed/commentcorrection/3422454-3079885,
http://linkedlifedata.com/resource/pubmed/commentcorrection/3422454-3091258,
http://linkedlifedata.com/resource/pubmed/commentcorrection/3422454-3096580,
http://linkedlifedata.com/resource/pubmed/commentcorrection/3422454-3510743,
http://linkedlifedata.com/resource/pubmed/commentcorrection/3422454-3561391,
http://linkedlifedata.com/resource/pubmed/commentcorrection/3422454-3748155,
http://linkedlifedata.com/resource/pubmed/commentcorrection/3422454-4075400,
http://linkedlifedata.com/resource/pubmed/commentcorrection/3422454-6146314,
http://linkedlifedata.com/resource/pubmed/commentcorrection/3422454-6246368,
http://linkedlifedata.com/resource/pubmed/commentcorrection/3422454-6248238,
http://linkedlifedata.com/resource/pubmed/commentcorrection/3422454-6269071,
http://linkedlifedata.com/resource/pubmed/commentcorrection/3422454-6275366,
http://linkedlifedata.com/resource/pubmed/commentcorrection/3422454-6329748,
http://linkedlifedata.com/resource/pubmed/commentcorrection/3422454-6540146,
http://linkedlifedata.com/resource/pubmed/commentcorrection/3422454-6609814,
http://linkedlifedata.com/resource/pubmed/commentcorrection/3422454-6828386,
http://linkedlifedata.com/resource/pubmed/commentcorrection/3422454-7358670,
http://linkedlifedata.com/resource/pubmed/commentcorrection/3422454-92183
|
|
pubmed:language |
eng
|
|
pubmed:journal |
|
|
pubmed:citationSubset |
IM
|
|
pubmed:chemical |
|
|
pubmed:status |
MEDLINE
|
|
pubmed:month |
Feb
|
|
pubmed:issn |
0027-8424
|
|
pubmed:author |
|
|
pubmed:issnType |
Print
|
|
pubmed:volume |
85
|
|
pubmed:owner |
NLM
|
|
pubmed:authorsComplete |
Y
|
|
pubmed:pagination |
723-7
|
|
pubmed:dateRevised |
2009-11-18
|
|
pubmed:meshHeading |
pubmed-meshheading:3422454-Animals,
pubmed-meshheading:3422454-Binding Sites,
pubmed-meshheading:3422454-DNA-Binding Proteins,
pubmed-meshheading:3422454-Enhancer Elements, Genetic,
pubmed-meshheading:3422454-Genes, MHC Class I,
pubmed-meshheading:3422454-Guanine,
pubmed-meshheading:3422454-H-2 Antigens,
pubmed-meshheading:3422454-Mice,
pubmed-meshheading:3422454-Nuclear Proteins,
pubmed-meshheading:3422454-Promoter Regions, Genetic,
pubmed-meshheading:3422454-Transcription Factors
|
|
pubmed:year |
1988
|
|
pubmed:articleTitle |
Two transcription factors, NF-kappa B and H2TF1, interact with a single regulatory sequence in the class I major histocompatibility complex promoter.
|
|
pubmed:affiliation |
Center for Cancer Research, Massachusetts Institute of Technology, Cambridge 02139.
|
|
pubmed:publicationType |
Journal Article,
Research Support, U.S. Gov't, P.H.S.,
Research Support, Non-U.S. Gov't
|
