Linked Life Data

3366932

Source:http://linkedlifedata.com/resource/pubmed/id/3366932

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
4
pubmed:dateCreated
1988-6-20
pubmed:abstractText
The validity of determining the progesterone receptor status of breast carcinomas with a monoclonal antibody was investigated by comparison with data from a radioligand binding assay on adjacent cryostat sections of 103 tumours. Significant nuclear staining for progesterone receptor was observed in 37 (36%) of the tumours studied and this showed a close correlation with the results of radioligand binding assays for progesterone receptor. In three progesterone receptor positive tumours there was an apparent paradoxical absence of oestrogen receptor; progesterone receptor normally depends on the presence of oestrogen receptor, but these rare tumours may be essentially progesterone receptor positive. It is concluded that this monoclonal antibody is an appropriate reagent for use in the immunohistological determination of progesterone receptor status of breast carcinomas; that it advantageously identifies both the occupied and unoccupied receptor sites; and that it provides information about tumour cell heterogeneity with respect to receptor status.
pubmed:commentsCorrections
http://linkedlifedata.com/resource/pubmed/commentcorrection/3366932-2435857, http://linkedlifedata.com/resource/pubmed/commentcorrection/3366932-2436753, http://linkedlifedata.com/resource/pubmed/commentcorrection/3366932-3305584, http://linkedlifedata.com/resource/pubmed/commentcorrection/3366932-3941149, http://linkedlifedata.com/resource/pubmed/commentcorrection/3366932-3950031, http://linkedlifedata.com/resource/pubmed/commentcorrection/3366932-4115981, http://linkedlifedata.com/resource/pubmed/commentcorrection/3366932-4862079, http://linkedlifedata.com/resource/pubmed/commentcorrection/3366932-6307615, http://linkedlifedata.com/resource/pubmed/commentcorrection/3366932-6579531, http://linkedlifedata.com/resource/pubmed/commentcorrection/3366932-6669985, http://linkedlifedata.com/resource/pubmed/commentcorrection/3366932-6833509
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
AIM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:month
Apr
pubmed:issn
0021-9746
pubmed:author
pubmed:issnType
Print
pubmed:volume
41
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
444-7
pubmed:dateRevised
2009-11-18
pubmed:meshHeading
pubmed:year
1988
pubmed:articleTitle
Immunohistological demonstration of progesterone receptor in breast carcinomas: correlation with radioligand binding assays and oestrogen receptor immunohistology.
pubmed:affiliation
Department of Pathology, University of Sheffield Medical School.
pubmed:publicationType
Journal Article, Research Support, Non-U.S. Gov't