Linked Life Data

3360691

Source:http://linkedlifedata.com/resource/pubmed/id/3360691

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
3
pubmed:dateCreated
1988-6-3
pubmed:abstractText
Gel electrophoresis revealed no plasmids in cloned strains of Ureaplasma urealyticum for which minimal inhibitory concentration (MICs) of tetracycline were greater than 64 mg/l. However, DNA from these strains hybridized with the tetM sequence from Streptococcus agalactiae in dot blot hybridization, whilst DNA from more-susceptible strains did not do so. Our results confirm and extend previous work, in which the tetM sequence was associated with resistance to the tetracycline antibiotics in strains of U. urealyticum. The strains examined in this study were isolated primarily in western North America but included representatives from Europe and the United Kingdom. Serotyping showed an increase in strains with the serotype 9 determinant and a decrease in those with the serotype 14 determinant together with a shift to the biotype 2 cluster (P = less than 0.02). To characterize these strains and to identify alternative antibiotics for therapeutic and basic research applications, 26 tetracycline-resistant strains were tested against 25 diverse antimicrobial agents. All demonstrated in-vitro susceptibility to rosaramicin but were resistant to 2 mg/l erythromycin. Only two of the strains were resistant to 16 mg/l erythromycin. Most antibiotics were not active against these isolates, but low concentrations of filipin and unconventional agents such as flurofamide and hydroquinone inhibited the growth of some strains.
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:month
Mar
pubmed:issn
0305-7453
pubmed:author
pubmed:issnType
Print
pubmed:volume
21
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
319-32
pubmed:dateRevised
2006-11-15
pubmed:meshHeading
pubmed:year
1988
pubmed:articleTitle
Characterization of tetracycline-resistant strains of Ureaplasma urealyticum.
pubmed:affiliation
Department of Medical Microbiology and Infectious Diseases, University of Alberta, Edmonton, Canada.
pubmed:publicationType
Journal Article, Research Support, Non-U.S. Gov't