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| Predicate | Object |
|---|---|
| rdf:type | |
| lifeskim:mentions | |
| pubmed:issue |
9
|
| pubmed:dateCreated |
1988-5-31
|
| pubmed:abstractText |
We have found no evidence for an adaptive response for either lethality or mutagenesis following treatment of Saccharomyces cerevisiae with N-methyl-N'-nitro-N-nitrosoguanidine (MNNG). The rad6 and rad52 mutants of S. cerevisiae are highly defective in MNNG and ethyl methanesulfonate induced mutagenesis of both stationary and exponential phase cells. These and other observations indicate that the mechanisms of repair of alkylation damage and mutagenesis differ markedly between S. cerevisiae and Escherichia coli.
|
| pubmed:grant | |
| pubmed:language |
eng
|
| pubmed:journal | |
| pubmed:citationSubset |
IM
|
| pubmed:chemical | |
| pubmed:status |
MEDLINE
|
| pubmed:issn |
0172-8083
|
| pubmed:author | |
| pubmed:issnType |
Print
|
| pubmed:volume |
10
|
| pubmed:owner |
NLM
|
| pubmed:authorsComplete |
Y
|
| pubmed:pagination |
647-55
|
| pubmed:dateRevised |
2007-11-14
|
| pubmed:meshHeading |
pubmed-meshheading:3329040-Adaptation, Physiological,
pubmed-meshheading:3329040-Alkylation,
pubmed-meshheading:3329040-Cell Cycle,
pubmed-meshheading:3329040-Cycloheximide,
pubmed-meshheading:3329040-DNA Repair,
pubmed-meshheading:3329040-Ethyl Methanesulfonate,
pubmed-meshheading:3329040-Genes, Fungal,
pubmed-meshheading:3329040-Methylnitronitrosoguanidine,
pubmed-meshheading:3329040-Mutation,
pubmed-meshheading:3329040-Saccharomyces cerevisiae
|
| pubmed:year |
1986
|
| pubmed:articleTitle |
Alkylation mutagenesis in Saccharomyces cerevisiae: lack of evidence for an adaptive response.
|
| pubmed:affiliation |
Department of Radiation Biology and Biophysics, University of Rochester School of Medicine, NY 14642.
|
| pubmed:publicationType |
Journal Article,
Research Support, U.S. Gov't, P.H.S.
|