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rdf:type |
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lifeskim:mentions |
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pubmed:issue |
6140
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pubmed:dateCreated |
1987-11-18
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pubmed:abstractText |
Over half of the inherited predisposition to insulin-dependent diabetes mellitus maps to the region of chromosome 6 that contains the highly polymorphic HLA class II genes which determine immune responsiveness. Analysis of DNA sequences from diabetics indicates that alleles of HLA-DQ beta determine both disease susceptibility and resistance, and that the structure of the DQ molecule, in particular residue 57 of the beta-chain, specifies the autoimmune response against the insulin-producing islet cells.
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
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pubmed:status |
MEDLINE
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pubmed:issn |
0028-0836
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pubmed:author |
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pubmed:issnType |
Print
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pubmed:volume |
329
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
599-604
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pubmed:dateRevised |
2010-11-18
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pubmed:meshHeading |
pubmed-meshheading:3309680-Alleles,
pubmed-meshheading:3309680-Amino Acid Sequence,
pubmed-meshheading:3309680-Base Sequence,
pubmed-meshheading:3309680-Chromosomes, Human, Pair 6,
pubmed-meshheading:3309680-Diabetes Mellitus, Type 1,
pubmed-meshheading:3309680-Disease Susceptibility,
pubmed-meshheading:3309680-Genetic Linkage,
pubmed-meshheading:3309680-HLA-D Antigens,
pubmed-meshheading:3309680-HLA-DQ Antigens,
pubmed-meshheading:3309680-HLA-DR Antigens,
pubmed-meshheading:3309680-Haploidy,
pubmed-meshheading:3309680-Histocompatibility Antigens Class II,
pubmed-meshheading:3309680-Humans,
pubmed-meshheading:3309680-Immunity, Innate,
pubmed-meshheading:3309680-Islets of Langerhans,
pubmed-meshheading:3309680-Molecular Sequence Data,
pubmed-meshheading:3309680-Oligonucleotides,
pubmed-meshheading:3309680-Polymorphism, Genetic
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pubmed:articleTitle |
HLA-DQ beta gene contributes to susceptibility and resistance to insulin-dependent diabetes mellitus.
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pubmed:affiliation |
Department of Medical Microbiology, Stanford University School of Medicine, California 94305.
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pubmed:publicationType |
Journal Article,
Research Support, U.S. Gov't, P.H.S.,
Research Support, Non-U.S. Gov't
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