| pubmed-article:329934 | rdf:type | pubmed:Citation | lld:pubmed |
| pubmed-article:329934 | lifeskim:mentions | umls-concept:C0040300 | lld:lifeskim |
| pubmed-article:329934 | lifeskim:mentions | umls-concept:C0999699 | lld:lifeskim |
| pubmed-article:329934 | lifeskim:mentions | umls-concept:C0439849 | lld:lifeskim |
| pubmed-article:329934 | lifeskim:mentions | umls-concept:C0002792 | lld:lifeskim |
| pubmed-article:329934 | lifeskim:mentions | umls-concept:C0014264 | lld:lifeskim |
| pubmed-article:329934 | lifeskim:mentions | umls-concept:C0600688 | lld:lifeskim |
| pubmed-article:329934 | pubmed:issue | 3 | lld:pubmed |
| pubmed-article:329934 | pubmed:dateCreated | 1977-10-28 | lld:pubmed |
| pubmed-article:329934 | pubmed:abstractText | 1 A lipopolysaccharide extract of Escherichia coli 026:B6 cells (026:B6(B) endotoxin) was shown to be toxic to normal adult guinea-pigs. 2 The agent had no action on isolated preparations of ileum and heart taken from normal adult guinea-pigs. 3 Ileal segments from animals actively immunized against 026:B6(B) endotoxin showed dose-dependent contractions when exposed to endotoxin. Desensitization phenomena were demonstrated. 4 Reactivity of 026:B6(B) endotoxin was transferred to isolated preparations of ileum and heart from normal animals by passive transfer of immune serum. 5 Tissue responses to 026:B6(B) were associated with release of ileal spasmogen into the bath medium. Mepyramine blocked the effects of this spasmogen at bath concentrations which caused little change in ileal responses to carbachol. 6 It is concluded that E. coli endotoxin can elicit anaphylactic reactions, and that this process may potentiate endotoxin toxicity in sensitized animals. However, endotoxin toxicity in guinea-pigs does not appear to depend on this kind of allergic process. | lld:pubmed |
| pubmed-article:329934 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
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| pubmed-article:329934 | pubmed:language | eng | lld:pubmed |
| pubmed-article:329934 | pubmed:journal | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:329934 | pubmed:citationSubset | IM | lld:pubmed |
| pubmed-article:329934 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:329934 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:329934 | pubmed:status | MEDLINE | lld:pubmed |
| pubmed-article:329934 | pubmed:month | Jul | lld:pubmed |
| pubmed-article:329934 | pubmed:issn | 0007-1188 | lld:pubmed |
| pubmed-article:329934 | pubmed:author | pubmed-author:McLeanA JAJ | lld:pubmed |
| pubmed-article:329934 | pubmed:issnType | Print | lld:pubmed |
| pubmed-article:329934 | pubmed:volume | 60 | lld:pubmed |
| pubmed-article:329934 | pubmed:owner | NLM | lld:pubmed |
| pubmed-article:329934 | pubmed:authorsComplete | Y | lld:pubmed |
| pubmed-article:329934 | pubmed:pagination | 369-73 | lld:pubmed |
| pubmed-article:329934 | pubmed:dateRevised | 2009-11-18 | lld:pubmed |
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| pubmed-article:329934 | pubmed:meshHeading | pubmed-meshheading:329934-I... | lld:pubmed |
| pubmed-article:329934 | pubmed:year | 1977 | lld:pubmed |
| pubmed-article:329934 | pubmed:articleTitle | Anaphylactic reactions to endotoxin in guinea-pig tissues: relationship to endotoxin toxicity. | lld:pubmed |
| pubmed-article:329934 | pubmed:publicationType | Journal Article | lld:pubmed |
| pubmed-article:329934 | pubmed:publicationType | In Vitro | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:329934 | lld:pubmed |
