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rdf:type |
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lifeskim:mentions |
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pubmed:issue |
3
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pubmed:dateCreated |
1977-10-28
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pubmed:abstractText |
1 A lipopolysaccharide extract of Escherichia coli 026:B6 cells (026:B6(B) endotoxin) was shown to be toxic to normal adult guinea-pigs. 2 The agent had no action on isolated preparations of ileum and heart taken from normal adult guinea-pigs. 3 Ileal segments from animals actively immunized against 026:B6(B) endotoxin showed dose-dependent contractions when exposed to endotoxin. Desensitization phenomena were demonstrated. 4 Reactivity of 026:B6(B) endotoxin was transferred to isolated preparations of ileum and heart from normal animals by passive transfer of immune serum. 5 Tissue responses to 026:B6(B) were associated with release of ileal spasmogen into the bath medium. Mepyramine blocked the effects of this spasmogen at bath concentrations which caused little change in ileal responses to carbachol. 6 It is concluded that E. coli endotoxin can elicit anaphylactic reactions, and that this process may potentiate endotoxin toxicity in sensitized animals. However, endotoxin toxicity in guinea-pigs does not appear to depend on this kind of allergic process.
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pubmed:commentsCorrections |
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
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pubmed:status |
MEDLINE
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pubmed:month |
Jul
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|
pubmed:issn |
0007-1188
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pubmed:author |
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pubmed:issnType |
Print
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pubmed:volume |
60
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
369-73
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pubmed:dateRevised |
2009-11-18
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pubmed:meshHeading |
pubmed-meshheading:329934-Anaphylaxis,
pubmed-meshheading:329934-Animals,
pubmed-meshheading:329934-Endotoxins,
pubmed-meshheading:329934-Escherichia coli,
pubmed-meshheading:329934-Guinea Pigs,
pubmed-meshheading:329934-Heart Rate,
pubmed-meshheading:329934-Ileum,
pubmed-meshheading:329934-Immune Sera,
pubmed-meshheading:329934-Immunity, Maternally-Acquired,
pubmed-meshheading:329934-Immunization,
pubmed-meshheading:329934-Muscle, Smooth,
pubmed-meshheading:329934-Muscle Contraction,
pubmed-meshheading:329934-Myocardial Contraction
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pubmed:year |
1977
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pubmed:articleTitle |
Anaphylactic reactions to endotoxin in guinea-pig tissues: relationship to endotoxin toxicity.
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pubmed:publicationType |
Journal Article,
In Vitro
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