| pubmed-article:3261346 | rdf:type | pubmed:Citation | lld:pubmed |
| pubmed-article:3261346 | lifeskim:mentions | umls-concept:C0027651 | lld:lifeskim |
| pubmed-article:3261346 | lifeskim:mentions | umls-concept:C1006246 | lld:lifeskim |
| pubmed-article:3261346 | lifeskim:mentions | umls-concept:C0025919 | lld:lifeskim |
| pubmed-article:3261346 | lifeskim:mentions | umls-concept:C0026473 | lld:lifeskim |
| pubmed-article:3261346 | lifeskim:mentions | umls-concept:C1708726 | lld:lifeskim |
| pubmed-article:3261346 | lifeskim:mentions | umls-concept:C0018284 | lld:lifeskim |
| pubmed-article:3261346 | lifeskim:mentions | umls-concept:C1158478 | lld:lifeskim |
| pubmed-article:3261346 | lifeskim:mentions | umls-concept:C1705422 | lld:lifeskim |
| pubmed-article:3261346 | lifeskim:mentions | umls-concept:C0591833 | lld:lifeskim |
| pubmed-article:3261346 | pubmed:issue | 9 | lld:pubmed |
| pubmed-article:3261346 | pubmed:dateCreated | 1988-9-20 | lld:pubmed |
| pubmed-article:3261346 | pubmed:abstractText | The development of tumors is thought to be a multistage process that requires an unknown number of genetic or epigenetic changes in a single cell. We previously described a murine monocyte tumor which was induced by a helper-free c-myc retrovirus and which also contained a DNA rearrangement at the colony-stimulating factor-1 (CSF-1) locus. The CSF-1 gene rearrangement gave rise to high levels of growth factor production and autocrine growth, implicating this secondary event in tumorigenesis. This CSF-1 gene rearrangement was found to be the result of integration of the BALB/c ecotropic retrovirus. Restriction enzyme mapping and DNA sequence analysis demonstrated that the novel provirus is identical to the BALB/c endogenous ecotropic provirus, indicating that infection was probably not due to the creation of a recombinant virus in vivo. The proviral integration site was mapped 3 kilobases 5' of the CSF-1 promoter and in an opposite transcriptional orientation, indicating that activation of CSF-1 expression was the result of the presence of the retroviral enhancer element. | lld:pubmed |
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| pubmed-article:3261346 | pubmed:language | eng | lld:pubmed |
| pubmed-article:3261346 | pubmed:journal | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:3261346 | pubmed:citationSubset | IM | lld:pubmed |
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| pubmed-article:3261346 | pubmed:status | MEDLINE | lld:pubmed |
| pubmed-article:3261346 | pubmed:month | Sep | lld:pubmed |
| pubmed-article:3261346 | pubmed:issn | 0022-538X | lld:pubmed |
| pubmed-article:3261346 | pubmed:author | pubmed-author:BaumbachW RWR | lld:pubmed |
| pubmed-article:3261346 | pubmed:author | pubmed-author:ColeM DMD | lld:pubmed |
| pubmed-article:3261346 | pubmed:author | pubmed-author:ColstonE MEM | lld:pubmed |
| pubmed-article:3261346 | pubmed:issnType | Print | lld:pubmed |
| pubmed-article:3261346 | pubmed:volume | 62 | lld:pubmed |
| pubmed-article:3261346 | pubmed:owner | NLM | lld:pubmed |
| pubmed-article:3261346 | pubmed:authorsComplete | Y | lld:pubmed |
| pubmed-article:3261346 | pubmed:pagination | 3151-5 | lld:pubmed |
| pubmed-article:3261346 | pubmed:dateRevised | 2009-11-18 | lld:pubmed |
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| pubmed-article:3261346 | pubmed:year | 1988 | lld:pubmed |
| pubmed-article:3261346 | pubmed:articleTitle | Integration of the BALB/c ecotropic provirus into the colony-stimulating factor-1 growth factor locus in a myc retrovirus-induced murine monocyte tumor. | lld:pubmed |
| pubmed-article:3261346 | pubmed:affiliation | Department of Molecular Biology, Princeton University, New Jersey 08544. | lld:pubmed |
| pubmed-article:3261346 | pubmed:publicationType | Journal Article | lld:pubmed |
| pubmed-article:3261346 | pubmed:publicationType | Research Support, U.S. Gov't, P.H.S. | lld:pubmed |
| pubmed-article:3261346 | pubmed:publicationType | Research Support, Non-U.S. Gov't | lld:pubmed |
| entrez-gene:12977 | entrezgene:pubmed | pubmed-article:3261346 | lld:entrezgene |
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