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rdf:type |
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lifeskim:mentions |
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pubmed:issue |
9
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pubmed:dateCreated |
1988-9-20
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pubmed:abstractText |
The development of tumors is thought to be a multistage process that requires an unknown number of genetic or epigenetic changes in a single cell. We previously described a murine monocyte tumor which was induced by a helper-free c-myc retrovirus and which also contained a DNA rearrangement at the colony-stimulating factor-1 (CSF-1) locus. The CSF-1 gene rearrangement gave rise to high levels of growth factor production and autocrine growth, implicating this secondary event in tumorigenesis. This CSF-1 gene rearrangement was found to be the result of integration of the BALB/c ecotropic retrovirus. Restriction enzyme mapping and DNA sequence analysis demonstrated that the novel provirus is identical to the BALB/c endogenous ecotropic provirus, indicating that infection was probably not due to the creation of a recombinant virus in vivo. The proviral integration site was mapped 3 kilobases 5' of the CSF-1 promoter and in an opposite transcriptional orientation, indicating that activation of CSF-1 expression was the result of the presence of the retroviral enhancer element.
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pubmed:commentsCorrections |
http://linkedlifedata.com/resource/pubmed/commentcorrection/3261346-2413359,
http://linkedlifedata.com/resource/pubmed/commentcorrection/3261346-271968,
http://linkedlifedata.com/resource/pubmed/commentcorrection/3261346-2987696,
http://linkedlifedata.com/resource/pubmed/commentcorrection/3261346-2993654,
http://linkedlifedata.com/resource/pubmed/commentcorrection/3261346-2996129,
http://linkedlifedata.com/resource/pubmed/commentcorrection/3261346-2999434,
http://linkedlifedata.com/resource/pubmed/commentcorrection/3261346-3010125,
http://linkedlifedata.com/resource/pubmed/commentcorrection/3261346-3016297,
http://linkedlifedata.com/resource/pubmed/commentcorrection/3261346-3020426,
http://linkedlifedata.com/resource/pubmed/commentcorrection/3261346-3027579,
http://linkedlifedata.com/resource/pubmed/commentcorrection/3261346-3028245,
http://linkedlifedata.com/resource/pubmed/commentcorrection/3261346-3091854,
http://linkedlifedata.com/resource/pubmed/commentcorrection/3261346-3296190,
http://linkedlifedata.com/resource/pubmed/commentcorrection/3261346-3493529,
http://linkedlifedata.com/resource/pubmed/commentcorrection/3261346-3500041,
http://linkedlifedata.com/resource/pubmed/commentcorrection/3261346-3547079,
http://linkedlifedata.com/resource/pubmed/commentcorrection/3261346-3877307,
http://linkedlifedata.com/resource/pubmed/commentcorrection/3261346-3883191,
http://linkedlifedata.com/resource/pubmed/commentcorrection/3261346-3906410,
http://linkedlifedata.com/resource/pubmed/commentcorrection/3261346-6098468,
http://linkedlifedata.com/resource/pubmed/commentcorrection/3261346-6169994,
http://linkedlifedata.com/resource/pubmed/commentcorrection/3261346-6254003,
http://linkedlifedata.com/resource/pubmed/commentcorrection/3261346-6287001,
http://linkedlifedata.com/resource/pubmed/commentcorrection/3261346-6305503,
http://linkedlifedata.com/resource/pubmed/commentcorrection/3261346-6308472,
http://linkedlifedata.com/resource/pubmed/commentcorrection/3261346-6313211,
http://linkedlifedata.com/resource/pubmed/commentcorrection/3261346-6319746,
http://linkedlifedata.com/resource/pubmed/commentcorrection/3261346-6320713,
http://linkedlifedata.com/resource/pubmed/commentcorrection/3261346-6326095,
http://linkedlifedata.com/resource/pubmed/commentcorrection/3261346-6397126,
http://linkedlifedata.com/resource/pubmed/commentcorrection/3261346-6498938,
http://linkedlifedata.com/resource/pubmed/commentcorrection/3261346-6678608,
http://linkedlifedata.com/resource/pubmed/commentcorrection/3261346-6683594
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
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pubmed:status |
MEDLINE
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pubmed:month |
Sep
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pubmed:issn |
0022-538X
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pubmed:author |
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pubmed:issnType |
Print
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pubmed:volume |
62
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
3151-5
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pubmed:dateRevised |
2009-11-18
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pubmed:meshHeading |
pubmed-meshheading:3261346-Animals,
pubmed-meshheading:3261346-Cloning, Molecular,
pubmed-meshheading:3261346-Colony-Stimulating Factors,
pubmed-meshheading:3261346-DNA, Viral,
pubmed-meshheading:3261346-Enhancer Elements, Genetic,
pubmed-meshheading:3261346-Gene Expression Regulation,
pubmed-meshheading:3261346-Mice,
pubmed-meshheading:3261346-Monocytes,
pubmed-meshheading:3261346-Nucleic Acid Hybridization,
pubmed-meshheading:3261346-Promoter Regions, Genetic,
pubmed-meshheading:3261346-Proviruses,
pubmed-meshheading:3261346-RNA, Messenger,
pubmed-meshheading:3261346-RNA, Viral,
pubmed-meshheading:3261346-Recombination, Genetic,
pubmed-meshheading:3261346-Retroviridae,
pubmed-meshheading:3261346-Tumor Virus Infections
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pubmed:year |
1988
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pubmed:articleTitle |
Integration of the BALB/c ecotropic provirus into the colony-stimulating factor-1 growth factor locus in a myc retrovirus-induced murine monocyte tumor.
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pubmed:affiliation |
Department of Molecular Biology, Princeton University, New Jersey 08544.
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pubmed:publicationType |
Journal Article,
Research Support, U.S. Gov't, P.H.S.,
Research Support, Non-U.S. Gov't
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