| pubmed-article:3260285 | rdf:type | pubmed:Citation | lld:pubmed |
| pubmed-article:3260285 | lifeskim:mentions | umls-concept:C0040300 | lld:lifeskim |
| pubmed-article:3260285 | lifeskim:mentions | umls-concept:C0034833 | lld:lifeskim |
| pubmed-article:3260285 | lifeskim:mentions | umls-concept:C0220781 | lld:lifeskim |
| pubmed-article:3260285 | lifeskim:mentions | umls-concept:C1883254 | lld:lifeskim |
| pubmed-article:3260285 | lifeskim:mentions | umls-concept:C0032743 | lld:lifeskim |
| pubmed-article:3260285 | lifeskim:mentions | umls-concept:C0243144 | lld:lifeskim |
| pubmed-article:3260285 | lifeskim:mentions | umls-concept:C0597354 | lld:lifeskim |
| pubmed-article:3260285 | lifeskim:mentions | umls-concept:C1705938 | lld:lifeskim |
| pubmed-article:3260285 | lifeskim:mentions | umls-concept:C1521840 | lld:lifeskim |
| pubmed-article:3260285 | lifeskim:mentions | umls-concept:C1527178 | lld:lifeskim |
| pubmed-article:3260285 | pubmed:issue | 7 | lld:pubmed |
| pubmed-article:3260285 | pubmed:dateCreated | 1988-8-5 | lld:pubmed |
| pubmed-article:3260285 | pubmed:abstractText | We have synthesized 21-[18F]fluoro-16 alpha-ethyl-19-norprogesterone (FENP), a high affinity ligand for the progesterone receptor, labeled with the positron-emitting radionuclide fluorine-18 (t1/2 = 110 min). The synthesis proceeds in two steps from 21-hydroxy-16 alpha-ethyl-19-norprogesterone and involves [18F]fluoride ion displacement of the 21-trifluoromethanesulfonate (21-triflate). This material is purified by HPLC and is obtained in 4-30% overall yield (decay corrected) within 40 min after the end of bombardment to produce [18F]fluoride ion. The effective specific activity, determined by competitive radioreceptor binding assays, is 700-1400 Ci/mmol. In vivo, [18F]FENP demonstrates highly selective, receptor-mediated uptake by the uterus of estrogen-primed rats; the uterus to blood and uterus to muscle ratios were respectively 26 and 16 at 1 h and 71 and 41 at 3 h after injection. The high target tissue selectivity of this uptake suggests that this compound may be useful for the in vivo imaging of progestin target tissues and receptor-rich tumors (such as human breast tumors) by positron emission tomography. | lld:pubmed |
| pubmed-article:3260285 | pubmed:grant | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:3260285 | pubmed:language | eng | lld:pubmed |
| pubmed-article:3260285 | pubmed:journal | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:3260285 | pubmed:citationSubset | IM | lld:pubmed |
| pubmed-article:3260285 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:3260285 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:3260285 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:3260285 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:3260285 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:3260285 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:3260285 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:3260285 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:3260285 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:3260285 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:3260285 | pubmed:status | MEDLINE | lld:pubmed |
| pubmed-article:3260285 | pubmed:month | Jul | lld:pubmed |
| pubmed-article:3260285 | pubmed:issn | 0022-2623 | lld:pubmed |
| pubmed-article:3260285 | pubmed:author | pubmed-author:WelchM JMJ | lld:pubmed |
| pubmed-article:3260285 | pubmed:author | pubmed-author:MathiasC JCJ | lld:pubmed |
| pubmed-article:3260285 | pubmed:author | pubmed-author:Katzenellenbo... | lld:pubmed |
| pubmed-article:3260285 | pubmed:author | pubmed-author:PomperM GMG | lld:pubmed |
| pubmed-article:3260285 | pubmed:author | pubmed-author:BrodackJ WJW | lld:pubmed |
| pubmed-article:3260285 | pubmed:issnType | Print | lld:pubmed |
| pubmed-article:3260285 | pubmed:volume | 31 | lld:pubmed |
| pubmed-article:3260285 | pubmed:owner | NLM | lld:pubmed |
| pubmed-article:3260285 | pubmed:authorsComplete | Y | lld:pubmed |
| pubmed-article:3260285 | pubmed:pagination | 1360-3 | lld:pubmed |
| pubmed-article:3260285 | pubmed:dateRevised | 2008-11-21 | lld:pubmed |
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| pubmed-article:3260285 | pubmed:meshHeading | pubmed-meshheading:3260285-... | lld:pubmed |
| pubmed-article:3260285 | pubmed:year | 1988 | lld:pubmed |
| pubmed-article:3260285 | pubmed:articleTitle | 21-[18F]fluoro-16 alpha-ethyl-19-norprogesterone: synthesis and target tissue selective uptake of a progestin receptor based radiotracer for positron emission tomography. | lld:pubmed |
| pubmed-article:3260285 | pubmed:affiliation | Department of Chemistry, University of Illinois, Urbana 61801. | lld:pubmed |
| pubmed-article:3260285 | pubmed:publicationType | Journal Article | lld:pubmed |
| pubmed-article:3260285 | pubmed:publicationType | Comparative Study | lld:pubmed |
| pubmed-article:3260285 | pubmed:publicationType | Research Support, U.S. Gov't, P.H.S. | lld:pubmed |
| pubmed-article:3260285 | pubmed:publicationType | Research Support, U.S. Gov't, Non-P.H.S. | lld:pubmed |
| http://linkedlifedata.com/r... | http://linkedlifedata.com/r... | pubmed-article:3260285 | lld:chembl |
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| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:3260285 | lld:pubmed |
