Linked Life Data

3197699

Source:http://linkedlifedata.com/resource/pubmed/id/3197699

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
5
pubmed:dateCreated
1989-1-17
pubmed:abstractText
The anticonvulsant properties of the endogenous excitatory amino acid antagonist, kynurenic acid (KYA), were studied in prepubescent and adult rats using the amygdaloid kindling model of epilepsy. Treatment with intracerebroventricular KYA (360 nmoles (adult dose) or 240 nmoles (prepubescent dose] prior to administration of the electrical kindling stimulus significantly reduced the rate of kindling in both age groups. However, there was no significant difference between the KYA-treated and the controls in mean afterdischarge threshold in either age group. The results of this study indicate that with the kindling model KYA has a significant anticonvulsant effect in both prepubescent and adult rats.
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:issn
0920-1211
pubmed:author
pubmed:issnType
Print
pubmed:volume
2
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
302-8
pubmed:dateRevised
2006-11-15
pubmed:meshHeading
pubmed:articleTitle
Effects of kynurenic acid on amygdaloid kindling in the rat.
pubmed:affiliation
Department of Neurology, Medical College of Georgia, Augusta 30912.
pubmed:publicationType
Journal Article, Research Support, U.S. Gov't, Non-P.H.S., Research Support, Non-U.S. Gov't