Linked Life Data

3141992

Source:http://linkedlifedata.com/resource/pubmed/id/3141992

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pubmed-article:3141992pubmed:abstractTextWe studied the effect of the degree of fatty acid saturation on cholesterol metabolism in rats fed either a low cholesterol-low fat diet (control group), high cholesterol-low fat diet (Chol group), high cholesterol-high saturated fat diet (Chol-SF) or high cholesterol-high PUF diet (Chol-PUF). The highest serum cholesterol levels were found in the Chol-SF group. No significant difference in serum cholesterol was found between the Chol and Chol-PUF groups. The Chol-PUF group showed the greatest accumulation of cholesterol in the liver. There was no significant difference in fecal excretion of acidic sterols, cholesterol and coprostanol between the Chol-PUF and Chol-SF groups. We conclude that in chronic feeding experiments in rats: a) high dietary cholesterol intake results in hypercholesterolemia; b) the hypercholesterolemia is accentuated by high dietary SF but is unaffected by PUF; c) addition of PUF to high cholesterol diet leads to massive cholesterol accumulation in the liver which can partly account for the apparent hypocholesterolemic effect of PUF relative to SF; and d) differences in serum and tissue cholesterol levels between SF and PUF supplemented groups are unlikely to be due to their effects on fecal sterol excretion.lld:pubmed
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pubmed-article:3141992pubmed:authorpubmed-author:HollanderDDlld:pubmed
pubmed-article:3141992pubmed:authorpubmed-author:VaziriN DNDlld:pubmed
pubmed-article:3141992pubmed:authorpubmed-author:MartinR ARAlld:pubmed
pubmed-article:3141992pubmed:authorpubmed-author:DeardenLLlld:pubmed
pubmed-article:3141992pubmed:authorpubmed-author:RosarioLLlld:pubmed
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pubmed-article:3141992pubmed:pagination245-56lld:pubmed
pubmed-article:3141992pubmed:dateRevised2006-11-15lld:pubmed
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pubmed-article:3141992pubmed:articleTitleEffects of dietary fatty acid saturation on serum and tissue cholesterol concentrations and fecal sterol excretion: a chronic metabolic study in the rat.lld:pubmed
pubmed-article:3141992pubmed:affiliationDepartment of Medicine, University of California, Irvine 92717.lld:pubmed
pubmed-article:3141992pubmed:publicationTypeJournal Articlelld:pubmed