Linked Life Data

3141185

Source:http://linkedlifedata.com/resource/pubmed/id/3141185

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
3
pubmed:dateCreated
1988-12-21
pubmed:abstractText
In the present study, we have examined the cellular and subcellular distribution of talin in several tissues of the chicken. By immunocytochemistry, Western Blot analysis and [125I]vinculin overlay, talin was demonstrated in most of the main tissues and cell types of the body. Corresponding to the property of talin to bind to the fibronectin receptor, talin was found to be confined to the site of the plasma membrane that abuts the extracellular matrix in various types of mesenchymal and epithelial cells. In the central nervous system talin was almost exclusively confined to cells of the connective tissue, i.e., blood vessels and the connective tissue sheaths. No evidence was obtained for the association of talin with any type of intercellular junction. In nonadhering cells such as circulating platelets and leukocytes, talin displayed a diffuse distribution throughout the cytoplasm. These findings suggest a general role for talin in certain aspects of cellular adhesion to the extracellular matrix.
pubmed:grant
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:month
Aug
pubmed:issn
0171-9335
pubmed:author
pubmed:issnType
Print
pubmed:volume
46
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
513-22
pubmed:dateRevised
2007-11-14
pubmed:meshHeading
pubmed:year
1988
pubmed:articleTitle
Identification and subcellular location of talin in various cell types and tissues by means of [125I]vinculin overlay, immunoblotting and immunocytochemistry.
pubmed:affiliation
Department of Anatomy and Cell Biology, University of Marburg/Federal Republic of Germany.
pubmed:publicationType
Journal Article, Research Support, U.S. Gov't, P.H.S., Research Support, U.S. Gov't, Non-P.H.S., Research Support, Non-U.S. Gov't