Linked Life Data

3121361

Source:http://linkedlifedata.com/resource/pubmed/id/3121361

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
12
pubmed:dateCreated
1988-2-20
pubmed:abstractText
The FRTL-5 line of differentiated rat thyroid epithelial cells was shown to be sensitive to the cytotoxic action of recombinant tumor necrosis factor. The sensitivity of the cells varied with the conditions of culture. It was markedly increased by preincubation with recombinant interferon-gamma, and the magnitude of this enhancement was affected by the presence of thyroid-stimulating hormone. The increased susceptibility of the cells to the cytotoxicity of tumor necrosis factor was clear as early as 2-4 h after the addition of interferon-gamma and greatly preceded the induced expression of major histocompatibility complex class II antigen. Since cells secreting interferon-gamma and tumor necrosis factors may co-exist in inflammatory infiltrates, our observations suggest that these factors may be early mediators of cell destruction in autoimmune thyroid disease.
pubmed:grant
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:month
Dec
pubmed:issn
0014-2980
pubmed:author
pubmed:issnType
Print
pubmed:volume
17
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
1855-8
pubmed:dateRevised
2009-9-29
pubmed:meshHeading
pubmed:year
1987
pubmed:articleTitle
Cytotoxicity of tumor necrosis factor for thyroid epithelial cells and its regulation by interferon-gamma.
pubmed:affiliation
Department of Immunology, Middlesex Hospital Medical School, London, GB.
pubmed:publicationType
Journal Article, Research Support, Non-U.S. Gov't