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rdf:type |
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lifeskim:mentions |
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pubmed:issue |
8
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pubmed:dateCreated |
1987-12-4
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pubmed:abstractText |
Dexamethasone increases type 1 plasminogen activator inhibitor (PAI-1) activity released from the human fibrosarcoma cell line HT-1080. We demonstrated that dexamethasone caused about 10-fold increases in the intracellular and extracellular levels of PAI-1 protein, as measured by an enzyme-linked immunosorbent assay, in the rate of PAI-1 biosynthesis, and in the PAI-1 mRNA level. The effects on PAI-1 biosynthesis and mRNA level were detectable within 4 h and were maximal 16 to 24 h after the addition of dexamethasone. Cycloheximide did not inhibit the dexamethasone-induced increases in the capacity of the cells to synthesize PAI-1 and in the PAI-1 mRNA level.
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pubmed:commentsCorrections |
http://linkedlifedata.com/resource/pubmed/commentcorrection/3118190-13293190,
http://linkedlifedata.com/resource/pubmed/commentcorrection/3118190-2414726,
http://linkedlifedata.com/resource/pubmed/commentcorrection/3118190-2424117,
http://linkedlifedata.com/resource/pubmed/commentcorrection/3118190-2430793,
http://linkedlifedata.com/resource/pubmed/commentcorrection/3118190-2930999,
http://linkedlifedata.com/resource/pubmed/commentcorrection/3118190-2932100,
http://linkedlifedata.com/resource/pubmed/commentcorrection/3118190-3011558,
http://linkedlifedata.com/resource/pubmed/commentcorrection/3118190-3025016,
http://linkedlifedata.com/resource/pubmed/commentcorrection/3118190-3031083,
http://linkedlifedata.com/resource/pubmed/commentcorrection/3118190-3086313,
http://linkedlifedata.com/resource/pubmed/commentcorrection/3118190-3090045,
http://linkedlifedata.com/resource/pubmed/commentcorrection/3118190-3092219,
http://linkedlifedata.com/resource/pubmed/commentcorrection/3118190-3097076,
http://linkedlifedata.com/resource/pubmed/commentcorrection/3118190-3104349,
http://linkedlifedata.com/resource/pubmed/commentcorrection/3118190-3111844,
http://linkedlifedata.com/resource/pubmed/commentcorrection/3118190-3520936,
http://linkedlifedata.com/resource/pubmed/commentcorrection/3118190-3922076,
http://linkedlifedata.com/resource/pubmed/commentcorrection/3118190-3936043,
http://linkedlifedata.com/resource/pubmed/commentcorrection/3118190-5432063,
http://linkedlifedata.com/resource/pubmed/commentcorrection/3118190-6095813,
http://linkedlifedata.com/resource/pubmed/commentcorrection/3118190-6205392,
http://linkedlifedata.com/resource/pubmed/commentcorrection/3118190-6312282,
http://linkedlifedata.com/resource/pubmed/commentcorrection/3118190-6316340,
http://linkedlifedata.com/resource/pubmed/commentcorrection/3118190-632749,
http://linkedlifedata.com/resource/pubmed/commentcorrection/3118190-6365928,
http://linkedlifedata.com/resource/pubmed/commentcorrection/3118190-6541058,
http://linkedlifedata.com/resource/pubmed/commentcorrection/3118190-6646124,
http://linkedlifedata.com/resource/pubmed/commentcorrection/3118190-6678610,
http://linkedlifedata.com/resource/pubmed/commentcorrection/3118190-6736134,
http://linkedlifedata.com/resource/pubmed/commentcorrection/3118190-714156,
http://linkedlifedata.com/resource/pubmed/commentcorrection/3118190-7142289
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
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pubmed:status |
MEDLINE
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pubmed:month |
Aug
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pubmed:issn |
0270-7306
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pubmed:author |
|
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pubmed:issnType |
Print
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pubmed:volume |
7
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
3021-5
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pubmed:dateRevised |
2009-11-18
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pubmed:meshHeading |
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pubmed:year |
1987
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pubmed:articleTitle |
Plasminogen activator inhibitor type 1 biosynthesis and mRNA level are increased by dexamethasone in human fibrosarcoma cells.
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pubmed:affiliation |
Finsen Laboratory, Rigshospitalet, Copenhagen, Denmark.
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pubmed:publicationType |
Journal Article,
Research Support, Non-U.S. Gov't
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