rdf:type |
|
lifeskim:mentions |
umls-concept:C0009008,
umls-concept:C0014912,
umls-concept:C0018067,
umls-concept:C0021118,
umls-concept:C0021289,
umls-concept:C0021467,
umls-concept:C0021469,
umls-concept:C0033268,
umls-concept:C0040135,
umls-concept:C0376558,
umls-concept:C1527148
|
pubmed:issue |
3
|
pubmed:dateCreated |
1986-10-21
|
pubmed:abstractText |
Treatment of newborn rats with clomiphene citrate during the first 5 days of life gave rise to a marked decrease in body mass and to a still greater decrease in gonadal mass. A decrease was also observed in the testicular diameter of the males. The females showed a 43% increase in their estradiol levels over the control and an increase in the sensitivity to gonadotropins. Thyroxine level, which was also determined in view of the known gonadotropin-thyrotropin overlap, showed no change 6 weeks after pretreatment with clomiphene, while the thyroid gland responded to gonadotropin in the same manner as to thyrotropin.
|
pubmed:language |
eng
|
pubmed:journal |
|
pubmed:citationSubset |
IM
|
pubmed:chemical |
|
pubmed:status |
MEDLINE
|
pubmed:issn |
0231-424X
|
pubmed:author |
|
pubmed:issnType |
Print
|
pubmed:volume |
67
|
pubmed:owner |
NLM
|
pubmed:authorsComplete |
Y
|
pubmed:pagination |
343-7
|
pubmed:dateRevised |
2006-11-15
|
pubmed:meshHeading |
pubmed-meshheading:3092573-Animals,
pubmed-meshheading:3092573-Animals, Newborn,
pubmed-meshheading:3092573-Body Weight,
pubmed-meshheading:3092573-Clomiphene,
pubmed-meshheading:3092573-Estradiol Antagonists,
pubmed-meshheading:3092573-Estriol,
pubmed-meshheading:3092573-Female,
pubmed-meshheading:3092573-Follicle Stimulating Hormone,
pubmed-meshheading:3092573-Luteinizing Hormone,
pubmed-meshheading:3092573-Male,
pubmed-meshheading:3092573-Organ Size,
pubmed-meshheading:3092573-Ovary,
pubmed-meshheading:3092573-Rats,
pubmed-meshheading:3092573-Testis,
pubmed-meshheading:3092573-Thyroxine
|
pubmed:year |
1986
|
pubmed:articleTitle |
Influence of the neonatal (clomiphene) inhibition of estradiol imprinting on gonadal development and gonadal and thyroid hormone production later in life.
|
pubmed:publicationType |
Journal Article,
Comparative Study
|