| pubmed-article:3041594 | rdf:type | pubmed:Citation | lld:pubmed |
| pubmed-article:3041594 | lifeskim:mentions | umls-concept:C0043250 | lld:lifeskim |
| pubmed-article:3041594 | lifeskim:mentions | umls-concept:C0024432 | lld:lifeskim |
| pubmed-article:3041594 | lifeskim:mentions | umls-concept:C1171362 | lld:lifeskim |
| pubmed-article:3041594 | lifeskim:mentions | umls-concept:C0035696 | lld:lifeskim |
| pubmed-article:3041594 | lifeskim:mentions | umls-concept:C0040688 | lld:lifeskim |
| pubmed-article:3041594 | lifeskim:mentions | umls-concept:C0017262 | lld:lifeskim |
| pubmed-article:3041594 | lifeskim:mentions | umls-concept:C0018284 | lld:lifeskim |
| pubmed-article:3041594 | lifeskim:mentions | umls-concept:C1515670 | lld:lifeskim |
| pubmed-article:3041594 | lifeskim:mentions | umls-concept:C1285572 | lld:lifeskim |
| pubmed-article:3041594 | lifeskim:mentions | umls-concept:C1314763 | lld:lifeskim |
| pubmed-article:3041594 | lifeskim:mentions | umls-concept:C0936012 | lld:lifeskim |
| pubmed-article:3041594 | lifeskim:mentions | umls-concept:C1515655 | lld:lifeskim |
| pubmed-article:3041594 | pubmed:issue | 4866 | lld:pubmed |
| pubmed-article:3041594 | pubmed:dateCreated | 1988-9-8 | lld:pubmed |
| pubmed-article:3041594 | pubmed:abstractText | The presence of macrophages is required for the regeneration of many cell types during wound healing. Macrophages have been reported to express a wide range of mitogenic factors and cytokines, but none of these factors has been shown in vivo to sustain all the wound-healing processes. It has been suggested that transforming growth factor-alpha (TGF-alpha) may mediate angiogenesis, epidermal regrowth, and formation of granulation tissue in vivo. Macrophages isolated from a wound site, and not exposed to cell culture conditions, expressed messenger RNA transcripts for TGF-alpha, TGF-beta, platelet-derived growth factor A-chain, and insulin-like growth factor-1. The expression of these transcripts was determined by a novel method for RNA analysis in which low numbers of mouse macrophages were isolated from wound cylinders, their RNA was purified and reverse-transcribed, and the complementary DNA was amplified in a polymerase chain reaction primed with growth factor sequence-specific primers. This single-cell RNA phenotyping procedure is rapid and has the potential for quantification, and mRNA transcripts from a single cell or a few cells can be unambiguously demonstrated, with the simultaneous analysis of several mRNA species. Macrophages from wounds expressed TGF-alpha antigen, and wound fluids contained TGF-alpha. Elicited macrophages in culture also expressed TGF-alpha transcripts and polypeptide in a time-dependent manner after stimulation with modified low-density lipoproteins and lipopolysaccharide endotoxin, which are characteristic of the activators found in injured tissues. | lld:pubmed |
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| pubmed-article:3041594 | pubmed:language | eng | lld:pubmed |
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| pubmed-article:3041594 | pubmed:citationSubset | IM | lld:pubmed |
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| pubmed-article:3041594 | pubmed:status | MEDLINE | lld:pubmed |
| pubmed-article:3041594 | pubmed:month | Aug | lld:pubmed |
| pubmed-article:3041594 | pubmed:issn | 0036-8075 | lld:pubmed |
| pubmed-article:3041594 | pubmed:author | pubmed-author:WerbZZ | lld:pubmed |
| pubmed-article:3041594 | pubmed:author | pubmed-author:MarkDD | lld:pubmed |
| pubmed-article:3041594 | pubmed:author | pubmed-author:RappoleeD ADA | lld:pubmed |
| pubmed-article:3041594 | pubmed:author | pubmed-author:BandaM JMJ | lld:pubmed |
| pubmed-article:3041594 | pubmed:issnType | Print | lld:pubmed |
| pubmed-article:3041594 | pubmed:day | 5 | lld:pubmed |
| pubmed-article:3041594 | pubmed:volume | 241 | lld:pubmed |
| pubmed-article:3041594 | pubmed:owner | NLM | lld:pubmed |
| pubmed-article:3041594 | pubmed:authorsComplete | Y | lld:pubmed |
| pubmed-article:3041594 | pubmed:pagination | 708-12 | lld:pubmed |
| pubmed-article:3041594 | pubmed:dateRevised | 2007-11-14 | lld:pubmed |
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| pubmed-article:3041594 | pubmed:year | 1988 | lld:pubmed |
| pubmed-article:3041594 | pubmed:articleTitle | Wound macrophages express TGF-alpha and other growth factors in vivo: analysis by mRNA phenotyping. | lld:pubmed |
| pubmed-article:3041594 | pubmed:affiliation | Laboratory of Radiobiology and Environmental Health, University of California, San Francisco 94143. | lld:pubmed |
| pubmed-article:3041594 | pubmed:publicationType | Journal Article | lld:pubmed |
| pubmed-article:3041594 | pubmed:publicationType | Research Support, U.S. Gov't, P.H.S. | lld:pubmed |
| pubmed-article:3041594 | pubmed:publicationType | Research Support, U.S. Gov't, Non-P.H.S. | lld:pubmed |
| pubmed-article:3041594 | pubmed:publicationType | Research Support, Non-U.S. Gov't | lld:pubmed |
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