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rdf:type |
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lifeskim:mentions |
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pubmed:issue |
2
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pubmed:dateCreated |
1986-3-17
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pubmed:abstractText |
DBA/2 and Balb/c mice, both H-2d, develop myocardial inflammation and necrosis when infected with a heart-adapted strain of coxsackievirus Group B, Type 3. Similar inoculation of C57Bl/6 (H-2b) animals results in minimal myocarditis despite equivalent heart virus titers in the three stains. Thus, the host's genetic constitution influences the pathogenesis of the infection. Anti-mouse thymocyte serum and monoclonal Iad antibody effectively prevent myocarditis induction in DBA/2 and Balb/c mice, which demonstrates the importance of the immune system in this disease. Cytolytic T lymphocytes lysing virus-infected and uninfected myocytes and heart-reactive autoantibodies occur in both myocarditis-susceptible strains. Cellular immunity causes the myocardial injury in Balb/c mice. Complement depletion of Balb/c mice using cobra venom factor fails to alter the disease. Similar treatment of DBA/2 animals abrogates inflammation and necrosis, which suggests that heart-reactive antibodies in this strain are primarily responsible for initiating myocardial damage.
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pubmed:grant |
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pubmed:commentsCorrections |
http://linkedlifedata.com/resource/pubmed/commentcorrection/3004227-2858443,
http://linkedlifedata.com/resource/pubmed/commentcorrection/3004227-2984097,
http://linkedlifedata.com/resource/pubmed/commentcorrection/3004227-2985729,
http://linkedlifedata.com/resource/pubmed/commentcorrection/3004227-300399,
http://linkedlifedata.com/resource/pubmed/commentcorrection/3004227-4610045,
http://linkedlifedata.com/resource/pubmed/commentcorrection/3004227-4959665,
http://linkedlifedata.com/resource/pubmed/commentcorrection/3004227-6091924,
http://linkedlifedata.com/resource/pubmed/commentcorrection/3004227-6254364,
http://linkedlifedata.com/resource/pubmed/commentcorrection/3004227-6271873,
http://linkedlifedata.com/resource/pubmed/commentcorrection/3004227-6301994,
http://linkedlifedata.com/resource/pubmed/commentcorrection/3004227-6307010,
http://linkedlifedata.com/resource/pubmed/commentcorrection/3004227-6331168,
http://linkedlifedata.com/resource/pubmed/commentcorrection/3004227-6356861,
http://linkedlifedata.com/resource/pubmed/commentcorrection/3004227-6792282,
http://linkedlifedata.com/resource/pubmed/commentcorrection/3004227-6860402
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
AIM
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pubmed:chemical |
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pubmed:status |
MEDLINE
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pubmed:month |
Feb
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pubmed:issn |
0002-9440
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pubmed:author |
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pubmed:issnType |
Print
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pubmed:volume |
122
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
284-91
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pubmed:dateRevised |
2009-11-18
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pubmed:meshHeading |
pubmed-meshheading:3004227-Animals,
pubmed-meshheading:3004227-Antibodies, Viral,
pubmed-meshheading:3004227-Complement System Proteins,
pubmed-meshheading:3004227-Coxsackievirus Infections,
pubmed-meshheading:3004227-Cytotoxicity, Immunologic,
pubmed-meshheading:3004227-Enterovirus B, Human,
pubmed-meshheading:3004227-Heart,
pubmed-meshheading:3004227-Immunoglobulin G,
pubmed-meshheading:3004227-Immunoglobulin M,
pubmed-meshheading:3004227-Immunosuppression,
pubmed-meshheading:3004227-Male,
pubmed-meshheading:3004227-Mice,
pubmed-meshheading:3004227-Mice, Inbred BALB C,
pubmed-meshheading:3004227-Mice, Inbred DBA,
pubmed-meshheading:3004227-Myocarditis,
pubmed-meshheading:3004227-T-Lymphocytes
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pubmed:year |
1986
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pubmed:articleTitle |
Coxsackievirus B-3 myocarditis. Identification of different pathogenic mechanisms in DBA/2 and Balb/c mice.
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pubmed:publicationType |
Journal Article,
Comparative Study,
Research Support, U.S. Gov't, P.H.S.,
Research Support, Non-U.S. Gov't
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