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rdf:type |
|
|
lifeskim:mentions |
|
|
pubmed:issue |
2
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pubmed:dateCreated |
1985-10-31
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pubmed:abstractText |
Fragmented lung tissue prepared from human, ferret and guinea pig converted [3H]-leukotriene C4 ([3H]-LTC4) to [3H]-LTD4 and [3H]-LTE4. [3H]-LTD4 was the major product recovered from incubations with human and guinea pig lung, whereas [3H]-LTE4 was the predominant metabolite in ferret. Kinetic analysis in human lung yielded a much faster rate for the conversion of [3H]-LTC4 to [3H]-LTD4+E4 than for the conversion of [3H]-LTD4 to [3H]-LTE4. In all three species serine-borate complex blocked the metabolism of [3H]-LTC4, whereas L-cysteine blocked the metabolism of [3H]-LTD4. These studies demonstrate that guinea-pig and human lungs have a similar metabolic pattern and capacity which is dissimilar to the ferret.
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pubmed:language |
eng
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pubmed:journal |
|
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pubmed:citationSubset |
IM
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pubmed:chemical |
|
|
pubmed:status |
MEDLINE
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|
pubmed:month |
Sep
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|
pubmed:issn |
0006-291X
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|
pubmed:author |
|
|
pubmed:issnType |
Print
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pubmed:day |
16
|
|
pubmed:volume |
131
|
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pubmed:owner |
NLM
|
|
pubmed:authorsComplete |
Y
|
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pubmed:pagination |
892-8
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|
pubmed:dateRevised |
2006-11-15
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pubmed:meshHeading |
pubmed-meshheading:2996529-Animals,
pubmed-meshheading:2996529-Borates,
pubmed-meshheading:2996529-Carnivora,
pubmed-meshheading:2996529-Cysteine,
pubmed-meshheading:2996529-Ferrets,
pubmed-meshheading:2996529-Guinea Pigs,
pubmed-meshheading:2996529-Humans,
pubmed-meshheading:2996529-Kinetics,
pubmed-meshheading:2996529-Leukotriene E4,
pubmed-meshheading:2996529-Lung,
pubmed-meshheading:2996529-SRS-A,
pubmed-meshheading:2996529-Serine,
pubmed-meshheading:2996529-Species Specificity
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|
pubmed:year |
1985
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|
pubmed:articleTitle |
In vitro metabolism of [3H]-peptide leukotrienes in human and ferret lung: a comparison with the guinea pig.
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pubmed:publicationType |
Journal Article,
Comparative Study
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