Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:dateCreated
1987-2-17
pubmed:abstractText
To examine whether human atrial natriuretic peptide (hANP) has an agonistic effect on dopaminergic pathways, we studied the natriuretic action and the suppressive effect of hANP on aldosterone secretion before and during treatment with haloperidol or pergolide in nude mice harbouring heterotransplanted human CONN's adenoma tissue. Nude mice with heterotransplanted tumour material without hormonal activity served as controls. The natriuretic efficacy of hANP remained unchanged by haloperidol or pergolide both in controls and in nude mice with heterotransplanted CONN's adenoma tissue. On the other hand, hANP had no effect upon the haloperidol-induced increase in aldosterone excretion in the control animals. Thus, preliminary evidence emerges that hANP has no effect on dopaminergic pathways and that the aldosterone inhibiting action of hANP is only of minor physiological significance.
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:issn
0023-2173
pubmed:author
pubmed:issnType
Print
pubmed:volume
64 Suppl 6
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
47-9
pubmed:dateRevised
2004-11-17
pubmed:meshHeading
pubmed:year
1986
pubmed:articleTitle
Human atrial natriuretic peptide (hANP) has no effect upon dopaminergic pathways: preliminary evidence in nude mice bearing heterotransplanted human CONN's adenoma tissue.
pubmed:publicationType
Journal Article