Linked Life Data

2924076

Source:http://linkedlifedata.com/resource/pubmed/id/2924076

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
1
pubmed:dateCreated
1989-4-25
pubmed:abstractText
An anti-inflammatory corticosteroid, dexamethasone, was found to be a potent suppressor of cell sensitization induced by IgE antibody in a model of type I allergic inflammation in vivo. Low doses (approximately less than 10(-10) mol) of dexamethasone, administered intradermally to rabbits 90 min before injection of IgE into the same sites, suppressed local oedema induced by a local challenge with antigen 72 h later. The effect was not due to anti-inflammatory activity persisting in the skin site for the 3 day period. This novel potent activity of the corticosteroid may be an important component of its anti-allergic effect in diseases such as asthma.
pubmed:commentsCorrections
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:month
Jan
pubmed:issn
0007-1188
pubmed:author
pubmed:issnType
Print
pubmed:volume
96
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
5-7
pubmed:dateRevised
2009-11-18
pubmed:meshHeading
pubmed:year
1989
pubmed:articleTitle
An anti-inflammatory steroid inhibits tissue sensitization by IgE in vivo.
pubmed:affiliation
Section of Vascular Biology, MRC Clinical Research Centre, Harrow, Middlesex.
pubmed:publicationType
Journal Article, Research Support, Non-U.S. Gov't