Linked Life Data

2920307

Source:http://linkedlifedata.com/resource/pubmed/id/2920307

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
1
pubmed:dateCreated
1989-4-11
pubmed:abstractText
Elevated intracellular free cytosolic calcium in vascular smooth muscle cells has been suggested in the pathophysiology of hypertension and circulating factors in the plasma have been implicated. To investigate the role of these factors on calcium homeostasis in salt induced hypertension, calcium uptake was measured in aortae of Sprague-Dawley rats by plasma derived from Dahl salt sensitive and resistant rats given high (8.0%) and low (0.4%) salt diets, respectively, for four weeks. Calcium uptake was also measured in aortae of Dahl rats on these diets. Calcium uptake in aortae and systolic blood pressure were higher (P less than 0.001) in Dahl salt sensitive rats given a high salt diet as compared to those on a low salt diet. Plasma from salt sensitive rats on high salt diet increased calcium uptake (P less than 0.001) in aortae of Sprague-Dawley rats. In contrast, no changes in calcium uptake and systolic blood pressure were observed in Dahl salt resistant rats. The parallel increase in systolic blood pressure and calcium uptake in Dahl salt sensitive rats on high salt diet suggests that increased intracellular free calcium may be involved in the pathophysiology of hypertension. The increased calcium uptake seems to reflect an abnormality in calcium handling by the vessels. These data also demonstrate that plasma from salt sensitive rats on high salt diet increases calcium uptake in aortic tissue.
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:issn
0828-282X
pubmed:author
pubmed:issnType
Print
pubmed:volume
5
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
51-4
pubmed:dateRevised
2008-4-9
pubmed:meshHeading
pubmed:articleTitle
Increased calcium uptake in vascular tissue by plasma of salt induced hypertensive Dahl rats.
pubmed:affiliation
Department of Medicine, Memorial University of Newfoundland, St John's.
pubmed:publicationType
Journal Article, Research Support, Non-U.S. Gov't