Linked Life Data

2908807

Source:http://linkedlifedata.com/resource/pubmed/id/2908807

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:dateCreated
1993-6-21
pubmed:abstractText
Kindling was induced in Sprague-Dawley rats by repeated injection of pentylenetetrazol (PTZ, 30 mg/kg, IP). Somatostatin-like immunoreactivity (SLI) and 125I-Tyr-somatostatin binding were measured in different areas of the brain in saline-injected controls, rats receiving PTZ but not kindled (prekindled rats), and kindled rats. Compared to SLI levels in controls, SLI increased (p < 0.01) in the frontal cortex, striatum (p < 0.05 in kindled rats), and hippocampus of both prekindled and kindled animals. Hypothalamic levels of SLI remained unchanged. Compared with the controls, no change was found in somatostatin receptor binding in the frontal cortex, striatum or hippocampus in prekindled or kindled animals. These results suggest that an increased level of somatostatin may be connected to the development and maintenance of kindling.
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:issn
0196-9781
pubmed:author
pubmed:issnType
Print
pubmed:volume
9 Suppl 1
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
105-7
pubmed:dateRevised
2006-11-15
pubmed:meshHeading
pubmed:year
1988
pubmed:articleTitle
Somatostatin-like immunoreactivity and somatostatin receptor binding in rat brain in pentylenetetrazol-induced kindling.
pubmed:affiliation
Department of Neurology, University of Kuopio, Finland.
pubmed:publicationType
Journal Article, Comparative Study, Research Support, Non-U.S. Gov't