Switch to
Predicate | Object |
---|---|
rdf:type | |
lifeskim:mentions | |
pubmed:issue |
12A
|
pubmed:dateCreated |
1989-3-6
|
pubmed:abstractText |
A mouse gene, Cdx-1, was isolated from an embryonic cDNA library using a Drosophila caudal gene probe. The deduced amino acid sequence of Cdx-1 contains conserved sequence domains along the entire gene, as well as a highly conserved caudal-type homeo box. A structural comparison suggests a common ancestral origin of mouse Cdx-1 and Drosophila caudal. The expression of Cdx-1 during embryogenesis was analyzed by Northern blotting and in situ hybridization. Cdx-1-specific transcripts are localized in the epithelial lining of the intestines beginning at 14 days' gestation. The expression of Cdx-1 in the intestine continues into adulthood, but cannot be detected in any other tissues. The Cdx-1 gene is the first homeo-box-containing gene expressed in cells derived from the embryonic endoderm.
|
pubmed:language |
eng
|
pubmed:journal | |
pubmed:citationSubset |
IM
|
pubmed:chemical | |
pubmed:status |
MEDLINE
|
pubmed:month |
Dec
|
pubmed:issn |
0890-9369
|
pubmed:author | |
pubmed:issnType |
Print
|
pubmed:volume |
2
|
pubmed:owner |
NLM
|
pubmed:authorsComplete |
Y
|
pubmed:pagination |
1647-54
|
pubmed:dateRevised |
2006-11-15
|
pubmed:meshHeading |
pubmed-meshheading:2905686-Amino Acid Sequence,
pubmed-meshheading:2905686-Animals,
pubmed-meshheading:2905686-Base Sequence,
pubmed-meshheading:2905686-Blotting, Southern,
pubmed-meshheading:2905686-Chromosome Mapping,
pubmed-meshheading:2905686-DNA,
pubmed-meshheading:2905686-DNA Probes,
pubmed-meshheading:2905686-Drosophila,
pubmed-meshheading:2905686-Electrophoresis, Agar Gel,
pubmed-meshheading:2905686-Embryonic and Fetal Development,
pubmed-meshheading:2905686-Genes, Homeobox,
pubmed-meshheading:2905686-Intestines,
pubmed-meshheading:2905686-Mice,
pubmed-meshheading:2905686-Molecular Sequence Data,
pubmed-meshheading:2905686-Sequence Homology, Nucleic Acid,
pubmed-meshheading:2905686-Species Specificity,
pubmed-meshheading:2905686-Transcription, Genetic
|
pubmed:year |
1988
|
pubmed:articleTitle |
A mouse gene homologous to the Drosophila gene caudal is expressed in epithelial cells from the embryonic intestine.
|
pubmed:affiliation |
Department of Molecular Cell Biology, Max Planck Institute for Biophysical Chemistry, Göttingen, FRG.
|
pubmed:publicationType |
Journal Article,
Comparative Study,
Research Support, Non-U.S. Gov't
|