| pubmed-article:2899883 | rdf:type | pubmed:Citation | lld:pubmed |
| pubmed-article:2899883 | lifeskim:mentions | umls-concept:C0043393 | lld:lifeskim |
| pubmed-article:2899883 | lifeskim:mentions | umls-concept:C0024660 | lld:lifeskim |
| pubmed-article:2899883 | lifeskim:mentions | umls-concept:C0072108 | lld:lifeskim |
| pubmed-article:2899883 | lifeskim:mentions | umls-concept:C0079183 | lld:lifeskim |
| pubmed-article:2899883 | lifeskim:mentions | umls-concept:C0012890 | lld:lifeskim |
| pubmed-article:2899883 | lifeskim:mentions | umls-concept:C0598312 | lld:lifeskim |
| pubmed-article:2899883 | lifeskim:mentions | umls-concept:C1366837 | lld:lifeskim |
| pubmed-article:2899883 | pubmed:issue | 14A | lld:pubmed |
| pubmed-article:2899883 | pubmed:dateCreated | 1988-9-8 | lld:pubmed |
| pubmed-article:2899883 | pubmed:abstractText | Human cyclin/PCNA (proliferating cell nuclear antigen) is structurally, functionally, and immunologically homologous to the calf thymus auxiliary protein for DNA polymerase delta. This auxiliary protein has been investigated as a stimulatory factor for the nuclear DNA polymerases from S. cerevisiae. Calf cyclin/PCNA enhances by more than ten-fold the ability of DNA polymerase III to replicate templates with high template/primer ratios, e.g. poly(dA).oligo(dT) (40:1). The degree of stimulation increases with the template/primer ratio. At a high template/primer ratio, i.e. low primer density, cyclin/PCNA greatly increases processive DNA synthesis by DNA polymerase III. At low template/primer ratios (e.g. poly(dA).oligo(dT) (2.5:1), where addition of cyclin/PCNA only minimally increases the processivity of DNA polymerase III, a several-fold stimulation of total DNA synthesis is still observed. This indicates that cyclin/PCNA may also increase productive binding of DNA polymerase III to the template-primer and stabilize the template-primer-polymerase complex. The activity of yeast DNA polymerases I and II is not affected by addition of cyclin/PCNA. These results strengthen the hypothesis that yeast DNA polymerase III is functionally analogous to the mammalian DNA polymerase delta. | lld:pubmed |
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| pubmed-article:2899883 | pubmed:language | eng | lld:pubmed |
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| pubmed-article:2899883 | pubmed:citationSubset | IM | lld:pubmed |
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| pubmed-article:2899883 | pubmed:status | MEDLINE | lld:pubmed |
| pubmed-article:2899883 | pubmed:month | Jul | lld:pubmed |
| pubmed-article:2899883 | pubmed:issn | 0305-1048 | lld:pubmed |
| pubmed-article:2899883 | pubmed:author | pubmed-author:BurgersP MPM | lld:pubmed |
| pubmed-article:2899883 | pubmed:issnType | Print | lld:pubmed |
| pubmed-article:2899883 | pubmed:day | 25 | lld:pubmed |
| pubmed-article:2899883 | pubmed:volume | 16 | lld:pubmed |
| pubmed-article:2899883 | pubmed:owner | NLM | lld:pubmed |
| pubmed-article:2899883 | pubmed:authorsComplete | Y | lld:pubmed |
| pubmed-article:2899883 | pubmed:pagination | 6297-307 | lld:pubmed |
| pubmed-article:2899883 | pubmed:dateRevised | 2009-11-18 | lld:pubmed |
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| pubmed-article:2899883 | pubmed:meshHeading | pubmed-meshheading:2899883-... | lld:pubmed |
| pubmed-article:2899883 | pubmed:year | 1988 | lld:pubmed |
| pubmed-article:2899883 | pubmed:articleTitle | Mammalian cyclin/PCNA (DNA polymerase delta auxiliary protein) stimulates processive DNA synthesis by yeast DNA polymerase III. | lld:pubmed |
| pubmed-article:2899883 | pubmed:affiliation | Department of Biological Chemistry, Washington University School of Medicine, St. Louis, MO 63110. | lld:pubmed |
| pubmed-article:2899883 | pubmed:publicationType | Journal Article | lld:pubmed |
| pubmed-article:2899883 | pubmed:publicationType | In Vitro | lld:pubmed |
| pubmed-article:2899883 | pubmed:publicationType | Research Support, U.S. Gov't, P.H.S. | lld:pubmed |
| pubmed-article:2899883 | pubmed:publicationType | Research Support, Non-U.S. Gov't | lld:pubmed |
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