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rdf:type |
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lifeskim:mentions |
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pubmed:issue |
4858
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pubmed:dateCreated |
1988-7-14
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pubmed:abstractText |
The proliferating cell nuclear antigen (PCNA or cyclin) is a nuclear protein recently identified as a cofactor of DNA polymerase delta. When exponentially growing Balb/c3T3 cells are exposed to antisense oligodeoxynucleotides to PCNA, both DNA synthesis and mitosis are completely suppressed. A corresponding sense oligodeoxynucleotide has no inhibitory effects. These experiments indicate that PCNA (cyclin) is important in cellular DNA synthesis and in cell cycle progression.
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pubmed:grant |
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
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pubmed:status |
MEDLINE
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pubmed:month |
Jun
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pubmed:issn |
0036-8075
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pubmed:author |
|
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pubmed:issnType |
Print
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pubmed:day |
10
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pubmed:volume |
240
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
1544-6
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pubmed:dateRevised |
2007-11-14
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pubmed:meshHeading |
pubmed-meshheading:2897717-Animals,
pubmed-meshheading:2897717-Autoantigens,
pubmed-meshheading:2897717-Base Sequence,
pubmed-meshheading:2897717-Cell Division,
pubmed-meshheading:2897717-Cells, Cultured,
pubmed-meshheading:2897717-Codon,
pubmed-meshheading:2897717-DNA Replication,
pubmed-meshheading:2897717-Kinetics,
pubmed-meshheading:2897717-Mice,
pubmed-meshheading:2897717-Mice, Inbred BALB C,
pubmed-meshheading:2897717-Mitosis,
pubmed-meshheading:2897717-Molecular Sequence Data,
pubmed-meshheading:2897717-Nuclear Proteins,
pubmed-meshheading:2897717-Oligodeoxyribonucleotides,
pubmed-meshheading:2897717-Proliferating Cell Nuclear Antigen
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pubmed:year |
1988
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pubmed:articleTitle |
Inhibition of cellular proliferation by antisense oligodeoxynucleotides to PCNA cyclin.
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pubmed:affiliation |
Department of Pathology, Temple University Medical School, Philadelphia, PA 19140.
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pubmed:publicationType |
Journal Article,
Research Support, U.S. Gov't, P.H.S.,
Research Support, Non-U.S. Gov't
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