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| Predicate | Object |
|---|---|
| rdf:type | |
| lifeskim:mentions | |
| pubmed:issue |
8556
|
| pubmed:dateCreated |
1987-9-29
|
| pubmed:abstractText |
Male mice embryos deficient in hypoxanthine phosphoribosyl transferase (HPRT), derived from heterozygous (carrier) females and normal males, were diagnosed by biochemical microassay of HPRT activity in a single cell isolated from the eight-cell preimplantation embryo. The sampled embryos were transferred to recipient mothers and examined on the 14th day of gestation to confirm the accuracy of the preimplantation diagnosis. The diagnosis was sufficiently rapid that freezing of the embryos before transfer was not necessary. Of the embryos diagnosed as HPRT negative all 4 that grew into fetuses were correctly identified as HPRT-deficient males.
|
| pubmed:language |
eng
|
| pubmed:journal | |
| pubmed:citationSubset |
AIM
|
| pubmed:chemical | |
| pubmed:status |
MEDLINE
|
| pubmed:month |
Aug
|
| pubmed:issn |
0140-6736
|
| pubmed:author | |
| pubmed:issnType |
Print
|
| pubmed:day |
22
|
| pubmed:volume |
2
|
| pubmed:owner |
NLM
|
| pubmed:authorsComplete |
Y
|
| pubmed:pagination |
423-5
|
| pubmed:dateRevised |
2003-11-14
|
| pubmed:meshHeading |
pubmed-meshheading:2887727-Animals,
pubmed-meshheading:2887727-Blastomeres,
pubmed-meshheading:2887727-Disease Models, Animal,
pubmed-meshheading:2887727-Embryo Transfer,
pubmed-meshheading:2887727-Female,
pubmed-meshheading:2887727-Hypoxanthine Phosphoribosyltransferase,
pubmed-meshheading:2887727-Lesch-Nyhan Syndrome,
pubmed-meshheading:2887727-Male,
pubmed-meshheading:2887727-Mice,
pubmed-meshheading:2887727-Pregnancy,
pubmed-meshheading:2887727-Time Factors
|
| pubmed:year |
1987
|
| pubmed:articleTitle |
Preimplantation diagnosis of deficiency of hypoxanthine phosphoribosyl transferase in a mouse model for Lesch-Nyhan syndrome.
|
| pubmed:publicationType |
Journal Article
|