Linked Life Data

2854187

Source:http://linkedlifedata.com/resource/pubmed/id/2854187

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
1
pubmed:dateCreated
1989-6-8
pubmed:abstractText
Isogenic virulent/avirulent variants of Legionella pneumophila (Lp) were examined in vitro for their effect on PMN function as determined by measurement of peak chemiluminescence and superoxide anion production. When exposed to virulent/avirulent strains of Lp, PMN function was less than that seen following exposure to E. coli, the reduction of the oxidative burst being more pronounced with virulent Lp strains in both assays. To determine whether differences in reduced PMN function correlate with differences in complement component C3 binding by virulent and avirulent Lp, four pairs of organisms were incubated in normal human serum and examined by quantitative immunofluorescence. All strains of Lp bound less C3 than E. coli, although each to different degrees. Avirulent isogenic strains bound more C3 than their virulent counterparts with one exception. Depressed PMN function following exposure to Lp may be due to reduced C3 binding, although other virulence-associated factors may be involved.
pubmed:grant
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:month
Jul
pubmed:issn
0882-4010
pubmed:author
pubmed:issnType
Print
pubmed:volume
5
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
41-7
pubmed:dateRevised
2007-11-14
pubmed:meshHeading
pubmed:year
1988
pubmed:articleTitle
Interactions of virulent and avirulent Legionella pneumophila with human polymorphonuclear leukocytes.
pubmed:affiliation
Department of Microbiology and Immunology, University of Louisville School of Medicine, Kentucky 40292.
pubmed:publicationType
Journal Article, Comparative Study, Research Support, U.S. Gov't, P.H.S.