| pubmed-article:2837687 | rdf:type | pubmed:Citation | lld:pubmed |
| pubmed-article:2837687 | lifeskim:mentions | umls-concept:C0007765 | lld:lifeskim |
| pubmed-article:2837687 | lifeskim:mentions | umls-concept:C0596630 | lld:lifeskim |
| pubmed-article:2837687 | lifeskim:mentions | umls-concept:C0080093 | lld:lifeskim |
| pubmed-article:2837687 | lifeskim:mentions | umls-concept:C1280500 | lld:lifeskim |
| pubmed-article:2837687 | lifeskim:mentions | umls-concept:C1948023 | lld:lifeskim |
| pubmed-article:2837687 | pubmed:issue | 1-2 | lld:pubmed |
| pubmed-article:2837687 | pubmed:dateCreated | 1988-7-22 | lld:pubmed |
| pubmed-article:2837687 | pubmed:abstractText | N-methyl-D-aspartate (NMDA) supplementation of cerebellar cultures enriched in granule neurones (about 90%) prevented the extensive cell loss which occurs when cultivation takes place, in serum containing media, in the presence of 'low' K+ (5-15 mM). Estimation of tetanus toxin receptors and N-CAM contents indicated that NMDA rescued primarily nerve cells. The influence of NMDA in promoting cell survival was blocked by the receptor antagonist, 2-amino-5-phosphonovalerate. The effect depended both on the concentration of NMDA and on the degree of depolarization of cells, the affinity in the presence of 15 mM K+ being similar to that of NMDA receptor binding. The results attest a new role for excitatory amino acid transmitters by showing that they can exert a stage-dependent trophic action on developing nerve cells. | lld:pubmed |
| pubmed-article:2837687 | pubmed:language | eng | lld:pubmed |
| pubmed-article:2837687 | pubmed:journal | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:2837687 | pubmed:citationSubset | IM | lld:pubmed |
| pubmed-article:2837687 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
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| pubmed-article:2837687 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:2837687 | pubmed:status | MEDLINE | lld:pubmed |
| pubmed-article:2837687 | pubmed:month | Apr | lld:pubmed |
| pubmed-article:2837687 | pubmed:issn | 0304-3940 | lld:pubmed |
| pubmed-article:2837687 | pubmed:author | pubmed-author:JørgensenO... | lld:pubmed |
| pubmed-article:2837687 | pubmed:author | pubmed-author:BalázsRR | lld:pubmed |
| pubmed-article:2837687 | pubmed:author | pubmed-author:HadaYY | lld:pubmed |
| pubmed-article:2837687 | pubmed:issnType | Print | lld:pubmed |
| pubmed-article:2837687 | pubmed:day | 22 | lld:pubmed |
| pubmed-article:2837687 | pubmed:volume | 87 | lld:pubmed |
| pubmed-article:2837687 | pubmed:owner | NLM | lld:pubmed |
| pubmed-article:2837687 | pubmed:authorsComplete | Y | lld:pubmed |
| pubmed-article:2837687 | pubmed:pagination | 80-6 | lld:pubmed |
| pubmed-article:2837687 | pubmed:dateRevised | 2006-11-15 | lld:pubmed |
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| pubmed-article:2837687 | pubmed:meshHeading | pubmed-meshheading:2837687-... | lld:pubmed |
| pubmed-article:2837687 | pubmed:year | 1988 | lld:pubmed |
| pubmed-article:2837687 | pubmed:articleTitle | Stimulation of the N-methyl-D-aspartate receptor has a trophic effect on differentiating cerebellar granule cells. | lld:pubmed |
| pubmed-article:2837687 | pubmed:affiliation | MRC Developmental Neurobiology Unit, London, U.K. | lld:pubmed |
| pubmed-article:2837687 | pubmed:publicationType | Journal Article | lld:pubmed |
| pubmed-article:2837687 | pubmed:publicationType | Research Support, Non-U.S. Gov't | lld:pubmed |
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