| pubmed-article:2833334 | rdf:type | pubmed:Citation | lld:pubmed |
| pubmed-article:2833334 | lifeskim:mentions | umls-concept:C0079784 | lld:lifeskim |
| pubmed-article:2833334 | lifeskim:mentions | umls-concept:C0018183 | lld:lifeskim |
| pubmed-article:2833334 | lifeskim:mentions | umls-concept:C0019612 | lld:lifeskim |
| pubmed-article:2833334 | lifeskim:mentions | umls-concept:C0026473 | lld:lifeskim |
| pubmed-article:2833334 | lifeskim:mentions | umls-concept:C2349975 | lld:lifeskim |
| pubmed-article:2833334 | lifeskim:mentions | umls-concept:C1514485 | lld:lifeskim |
| pubmed-article:2833334 | pubmed:issue | 4 | lld:pubmed |
| pubmed-article:2833334 | pubmed:dateCreated | 1988-5-17 | lld:pubmed |
| pubmed-article:2833334 | pubmed:abstractText | Granulocyte-macrophage colony-stimulating factor (GM-CSF) is a specific humoral growth factor that stimulates both neutrophilic granulocyte and macrophage production by bone marrow hematopoietic progenitor cells. GM-CSF also stimulates the proliferation and clonal growth of both tissue macrophages and blood monocytes. Although at low concentrations GM-CSF was unable to support the long-term growth of tissue macrophages, it greatly enhanced their responsiveness to macrophage CSF (M-CSF, or CSF-1). This effect was also observed by treating macrophages with GM-CSF for a short time. GM-CSF did not compete with M-CSF for binding to M-CSF receptors nor was it inactivated by treatment with anti-M-CSF antiserum. Treatment of tissue macrophages with GM-CSF led to a rapid but transient downregulation of M-CSF receptors; prolonged incubation at 37 degrees C, however, resulted in a restoration and upregulation of M-CSF receptors. Identical effects were observed with both native or recombinant GM-CSF. This study suggests that GM-CSF regulates tissue macrophage production by two modes of action: (a) direct stimulation of macrophage proliferation, and (b) enhancement of their responsiveness to M-CSF. | lld:pubmed |
| pubmed-article:2833334 | pubmed:grant | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:2833334 | pubmed:language | eng | lld:pubmed |
| pubmed-article:2833334 | pubmed:journal | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:2833334 | pubmed:citationSubset | AIM | lld:pubmed |
| pubmed-article:2833334 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:2833334 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:2833334 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
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| pubmed-article:2833334 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:2833334 | pubmed:status | MEDLINE | lld:pubmed |
| pubmed-article:2833334 | pubmed:month | Apr | lld:pubmed |
| pubmed-article:2833334 | pubmed:issn | 0006-4971 | lld:pubmed |
| pubmed-article:2833334 | pubmed:author | pubmed-author:ChouT HTH | lld:pubmed |
| pubmed-article:2833334 | pubmed:author | pubmed-author:ClarkC RCR | lld:pubmed |
| pubmed-article:2833334 | pubmed:author | pubmed-author:ChenB DBD | lld:pubmed |
| pubmed-article:2833334 | pubmed:issnType | Print | lld:pubmed |
| pubmed-article:2833334 | pubmed:volume | 71 | lld:pubmed |
| pubmed-article:2833334 | pubmed:owner | NLM | lld:pubmed |
| pubmed-article:2833334 | pubmed:authorsComplete | Y | lld:pubmed |
| pubmed-article:2833334 | pubmed:pagination | 997-1002 | lld:pubmed |
| pubmed-article:2833334 | pubmed:dateRevised | 2007-11-14 | lld:pubmed |
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| pubmed-article:2833334 | pubmed:meshHeading | pubmed-meshheading:2833334-... | lld:pubmed |
| pubmed-article:2833334 | pubmed:meshHeading | pubmed-meshheading:2833334-... | lld:pubmed |
| pubmed-article:2833334 | pubmed:meshHeading | pubmed-meshheading:2833334-... | lld:pubmed |
| pubmed-article:2833334 | pubmed:meshHeading | pubmed-meshheading:2833334-... | lld:pubmed |
| pubmed-article:2833334 | pubmed:meshHeading | pubmed-meshheading:2833334-... | lld:pubmed |
| pubmed-article:2833334 | pubmed:year | 1988 | lld:pubmed |
| pubmed-article:2833334 | pubmed:articleTitle | Granulocyte/macrophage colony-stimulating factor stimulates monocyte and tissue macrophage proliferation and enhances their responsiveness to macrophage colony-stimulating factor. | lld:pubmed |
| pubmed-article:2833334 | pubmed:affiliation | Department of Internal Medicine, Wayne State University School of Medicine, Detroit, MI 48201. | lld:pubmed |
| pubmed-article:2833334 | pubmed:publicationType | Journal Article | lld:pubmed |
| pubmed-article:2833334 | pubmed:publicationType | Research Support, U.S. Gov't, P.H.S. | lld:pubmed |
| pubmed-article:2833334 | pubmed:publicationType | Research Support, Non-U.S. Gov't | lld:pubmed |
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