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| Predicate | Object |
|---|---|
| rdf:type | |
| lifeskim:mentions | |
| pubmed:issue |
4
|
| pubmed:dateCreated |
1988-5-17
|
| pubmed:abstractText |
Granulocyte-macrophage colony-stimulating factor (GM-CSF) is a specific humoral growth factor that stimulates both neutrophilic granulocyte and macrophage production by bone marrow hematopoietic progenitor cells. GM-CSF also stimulates the proliferation and clonal growth of both tissue macrophages and blood monocytes. Although at low concentrations GM-CSF was unable to support the long-term growth of tissue macrophages, it greatly enhanced their responsiveness to macrophage CSF (M-CSF, or CSF-1). This effect was also observed by treating macrophages with GM-CSF for a short time. GM-CSF did not compete with M-CSF for binding to M-CSF receptors nor was it inactivated by treatment with anti-M-CSF antiserum. Treatment of tissue macrophages with GM-CSF led to a rapid but transient downregulation of M-CSF receptors; prolonged incubation at 37 degrees C, however, resulted in a restoration and upregulation of M-CSF receptors. Identical effects were observed with both native or recombinant GM-CSF. This study suggests that GM-CSF regulates tissue macrophage production by two modes of action: (a) direct stimulation of macrophage proliferation, and (b) enhancement of their responsiveness to M-CSF.
|
| pubmed:grant | |
| pubmed:language |
eng
|
| pubmed:journal | |
| pubmed:citationSubset |
AIM
|
| pubmed:chemical |
http://linkedlifedata.com/resource/pubmed/chemical/Colony-Stimulating Factors,
http://linkedlifedata.com/resource/pubmed/chemical/Granulocyte-Macrophage...,
http://linkedlifedata.com/resource/pubmed/chemical/Growth Substances,
http://linkedlifedata.com/resource/pubmed/chemical/Receptors, Cell Surface,
http://linkedlifedata.com/resource/pubmed/chemical/Receptors, Colony-Stimulating Factor
|
| pubmed:status |
MEDLINE
|
| pubmed:month |
Apr
|
| pubmed:issn |
0006-4971
|
| pubmed:author | |
| pubmed:issnType |
Print
|
| pubmed:volume |
71
|
| pubmed:owner |
NLM
|
| pubmed:authorsComplete |
Y
|
| pubmed:pagination |
997-1002
|
| pubmed:dateRevised |
2007-11-14
|
| pubmed:meshHeading |
pubmed-meshheading:2833334-Animals,
pubmed-meshheading:2833334-Bone Marrow Cells,
pubmed-meshheading:2833334-Cell Adhesion,
pubmed-meshheading:2833334-Cell Division,
pubmed-meshheading:2833334-Colony-Forming Units Assay,
pubmed-meshheading:2833334-Colony-Stimulating Factors,
pubmed-meshheading:2833334-Drug Synergism,
pubmed-meshheading:2833334-Female,
pubmed-meshheading:2833334-Granulocyte-Macrophage Colony-Stimulating Factor,
pubmed-meshheading:2833334-Growth Substances,
pubmed-meshheading:2833334-Hematopoietic Stem Cells,
pubmed-meshheading:2833334-Macrophages,
pubmed-meshheading:2833334-Male,
pubmed-meshheading:2833334-Mice,
pubmed-meshheading:2833334-Mice, Inbred C3H,
pubmed-meshheading:2833334-Monocytes,
pubmed-meshheading:2833334-Peritoneal Cavity,
pubmed-meshheading:2833334-Receptors, Cell Surface,
pubmed-meshheading:2833334-Receptors, Colony-Stimulating Factor
|
| pubmed:year |
1988
|
| pubmed:articleTitle |
Granulocyte/macrophage colony-stimulating factor stimulates monocyte and tissue macrophage proliferation and enhances their responsiveness to macrophage colony-stimulating factor.
|
| pubmed:affiliation |
Department of Internal Medicine, Wayne State University School of Medicine, Detroit, MI 48201.
|
| pubmed:publicationType |
Journal Article,
Research Support, U.S. Gov't, P.H.S.,
Research Support, Non-U.S. Gov't
|