rdf:type |
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lifeskim:mentions |
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pubmed:dateCreated |
1988-3-18
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pubmed:abstractText |
Quantitative autoradiographic distribution patterns of sigma/PCP and NMDA receptors show striking similarities but not in all brain areas. We have identified an endogenous ligand of brain PCP receptors which noncompetitively antagonizes NMDA-induced neurotransmitter release from brain slices. These data support the concept that the sigma/PCP receptor ligands may exert their unique behavioral effects by indirect modulation of NMDA-mediated transmission.
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pubmed:grant |
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
http://linkedlifedata.com/resource/pubmed/chemical/Acetylcholine,
http://linkedlifedata.com/resource/pubmed/chemical/Aspartic Acid,
http://linkedlifedata.com/resource/pubmed/chemical/N-Methylaspartate,
http://linkedlifedata.com/resource/pubmed/chemical/Norepinephrine,
http://linkedlifedata.com/resource/pubmed/chemical/Receptors, N-Methyl-D-Aspartate,
http://linkedlifedata.com/resource/pubmed/chemical/Receptors, Neurotransmitter,
http://linkedlifedata.com/resource/pubmed/chemical/Receptors, Opioid,
http://linkedlifedata.com/resource/pubmed/chemical/Receptors, Phencyclidine,
http://linkedlifedata.com/resource/pubmed/chemical/Receptors, sigma
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pubmed:status |
MEDLINE
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pubmed:issn |
1046-9516
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pubmed:author |
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pubmed:issnType |
Print
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pubmed:volume |
75
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
157-60
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pubmed:dateRevised |
2007-11-14
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pubmed:meshHeading |
pubmed-meshheading:2828962-Acetylcholine,
pubmed-meshheading:2828962-Animals,
pubmed-meshheading:2828962-Aspartic Acid,
pubmed-meshheading:2828962-Brain,
pubmed-meshheading:2828962-Male,
pubmed-meshheading:2828962-N-Methylaspartate,
pubmed-meshheading:2828962-Norepinephrine,
pubmed-meshheading:2828962-Organ Specificity,
pubmed-meshheading:2828962-Rats,
pubmed-meshheading:2828962-Rats, Inbred Strains,
pubmed-meshheading:2828962-Receptors, N-Methyl-D-Aspartate,
pubmed-meshheading:2828962-Receptors, Neurotransmitter,
pubmed-meshheading:2828962-Receptors, Opioid,
pubmed-meshheading:2828962-Receptors, Phencyclidine,
pubmed-meshheading:2828962-Receptors, sigma
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pubmed:year |
1986
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pubmed:articleTitle |
Modulation of brain NMDA receptors: common mechanism of sigma/PCP receptors and their exogenous and endogenous ligands.
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pubmed:affiliation |
Department of Psychiatry, Albert Einstein College of Medicine, Bronx, NY.
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pubmed:publicationType |
Journal Article,
Research Support, U.S. Gov't, P.H.S.,
Research Support, Non-U.S. Gov't
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