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rdf:type |
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lifeskim:mentions |
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pubmed:issue |
4
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pubmed:dateCreated |
1989-10-3
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pubmed:abstractText |
Purified human and murine monocytes can be activated in vitro by human recombinant IL-2 to secrete tumour necrosis factor (TNF). TNF mRNA is detected within 4 h of addition of IL-2. Signal transduction does not appear to require expression of the Tac peptide of the IL-2 receptor. IL-2 does, however, induce Tac mRNA and Tac peptide expression on peripheral blood monocytes (PBM). In addition to these in vitro studies, PBM retrieved from IL-2-treated cancer patients and mice have been shown to have a greatly increased capacity for TNF production. These studies identify a pathway for macrophage activation by IL-2 both in vitro and in vivo. They also suggest a mechanism for some of the immunoregulatory and toxic effects of IL-2 based immunotherapy regimens.
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pubmed:grant |
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pubmed:commentsCorrections |
http://linkedlifedata.com/resource/pubmed/commentcorrection/2788610-2413547,
http://linkedlifedata.com/resource/pubmed/commentcorrection/2788610-2437650,
http://linkedlifedata.com/resource/pubmed/commentcorrection/2788610-2871106,
http://linkedlifedata.com/resource/pubmed/commentcorrection/2788610-3030546,
http://linkedlifedata.com/resource/pubmed/commentcorrection/2788610-3039002,
http://linkedlifedata.com/resource/pubmed/commentcorrection/2788610-3040856,
http://linkedlifedata.com/resource/pubmed/commentcorrection/2788610-3095481,
http://linkedlifedata.com/resource/pubmed/commentcorrection/2788610-3100957,
http://linkedlifedata.com/resource/pubmed/commentcorrection/2788610-3257980,
http://linkedlifedata.com/resource/pubmed/commentcorrection/2788610-3485132,
http://linkedlifedata.com/resource/pubmed/commentcorrection/2788610-3486936,
http://linkedlifedata.com/resource/pubmed/commentcorrection/2788610-3490903,
http://linkedlifedata.com/resource/pubmed/commentcorrection/2788610-3494061,
http://linkedlifedata.com/resource/pubmed/commentcorrection/2788610-3543677,
http://linkedlifedata.com/resource/pubmed/commentcorrection/2788610-3928750,
http://linkedlifedata.com/resource/pubmed/commentcorrection/2788610-6090949,
http://linkedlifedata.com/resource/pubmed/commentcorrection/2788610-6392892,
http://linkedlifedata.com/resource/pubmed/commentcorrection/2788610-6646124,
http://linkedlifedata.com/resource/pubmed/commentcorrection/2788610-6707477
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
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pubmed:status |
MEDLINE
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pubmed:month |
Aug
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pubmed:issn |
0019-2805
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pubmed:author |
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pubmed:issnType |
Print
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pubmed:volume |
67
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
514-9
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pubmed:dateRevised |
2009-11-18
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pubmed:meshHeading |
pubmed-meshheading:2788610-Animals,
pubmed-meshheading:2788610-Cells, Cultured,
pubmed-meshheading:2788610-Humans,
pubmed-meshheading:2788610-Interleukin-2,
pubmed-meshheading:2788610-Macrophage Activation,
pubmed-meshheading:2788610-Macrophages,
pubmed-meshheading:2788610-Mice,
pubmed-meshheading:2788610-Mice, Inbred C3H,
pubmed-meshheading:2788610-Recombinant Proteins,
pubmed-meshheading:2788610-Tumor Necrosis Factor-alpha
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pubmed:year |
1989
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pubmed:articleTitle |
Tumour necrosis factor production by IL-2-activated macrophages in vitro and in vivo.
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pubmed:affiliation |
John Wayne Cancer Clinic, UCLA School of Medicine 90024.
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pubmed:publicationType |
Journal Article,
Research Support, U.S. Gov't, P.H.S.
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