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rdf:type |
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lifeskim:mentions |
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pubmed:issue |
7
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pubmed:dateCreated |
1989-5-5
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pubmed:abstractText |
Tumor necrosis factor alpha (TNF-alpha), also known as cachectin, was demonstrated to induce the expression of human immunodeficiency virus (HIV) in a chronically infected T-cell clone (ACH-2). Concentrations of recombinant TNF-alpha as low as 50 pg/ml induced a significant increase over background of HIV expression in the ACH-2 cells as determined by supernatant reverse transcriptase activity. The HIV-inducing effects of TNF-alpha could not be explained by toxic effects on the cells. In addition, both the uninfected parental cell line (A3.01) and the infected ACH-2 cells were shown to have high-affinity receptors for TNF-alpha. Transient-transfection experiments demonstrated that the inductive effects of TNF-alpha were due to specific activation of the HIV long terminal repeat. These studies provide evidence that TNF-alpha may play a role in the mechanisms of pathogenesis of HIV infection.
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pubmed:commentsCorrections |
http://linkedlifedata.com/resource/pubmed/commentcorrection/2784570-1103152,
http://linkedlifedata.com/resource/pubmed/commentcorrection/2784570-2422271,
http://linkedlifedata.com/resource/pubmed/commentcorrection/2784570-2432602,
http://linkedlifedata.com/resource/pubmed/commentcorrection/2784570-2449497,
http://linkedlifedata.com/resource/pubmed/commentcorrection/2784570-2825201,
http://linkedlifedata.com/resource/pubmed/commentcorrection/2784570-2835680,
http://linkedlifedata.com/resource/pubmed/commentcorrection/2784570-2965212,
http://linkedlifedata.com/resource/pubmed/commentcorrection/2784570-2989831,
http://linkedlifedata.com/resource/pubmed/commentcorrection/2784570-2993897,
http://linkedlifedata.com/resource/pubmed/commentcorrection/2784570-2995927,
http://linkedlifedata.com/resource/pubmed/commentcorrection/2784570-3001529,
http://linkedlifedata.com/resource/pubmed/commentcorrection/2784570-3005411,
http://linkedlifedata.com/resource/pubmed/commentcorrection/2784570-3025748,
http://linkedlifedata.com/resource/pubmed/commentcorrection/2784570-3108447,
http://linkedlifedata.com/resource/pubmed/commentcorrection/2784570-3121735,
http://linkedlifedata.com/resource/pubmed/commentcorrection/2784570-3257102,
http://linkedlifedata.com/resource/pubmed/commentcorrection/2784570-3258616,
http://linkedlifedata.com/resource/pubmed/commentcorrection/2784570-3278061,
http://linkedlifedata.com/resource/pubmed/commentcorrection/2784570-3313729,
http://linkedlifedata.com/resource/pubmed/commentcorrection/2784570-3414726,
http://linkedlifedata.com/resource/pubmed/commentcorrection/2784570-3455781,
http://linkedlifedata.com/resource/pubmed/commentcorrection/2784570-3493285,
http://linkedlifedata.com/resource/pubmed/commentcorrection/2784570-3500512,
http://linkedlifedata.com/resource/pubmed/commentcorrection/2784570-3512757,
http://linkedlifedata.com/resource/pubmed/commentcorrection/2784570-3872925,
http://linkedlifedata.com/resource/pubmed/commentcorrection/2784570-6254391,
http://linkedlifedata.com/resource/pubmed/commentcorrection/2784570-6310145,
http://linkedlifedata.com/resource/pubmed/commentcorrection/2784570-6330891,
http://linkedlifedata.com/resource/pubmed/commentcorrection/2784570-6392892,
http://linkedlifedata.com/resource/pubmed/commentcorrection/2784570-6421983,
http://linkedlifedata.com/resource/pubmed/commentcorrection/2784570-6960240,
http://linkedlifedata.com/resource/pubmed/commentcorrection/2784570-7021422,
http://linkedlifedata.com/resource/pubmed/commentcorrection/2784570-7276825,
http://linkedlifedata.com/resource/pubmed/commentcorrection/2784570-7464858
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
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pubmed:status |
MEDLINE
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pubmed:month |
Apr
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pubmed:issn |
0027-8424
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pubmed:author |
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pubmed:issnType |
Print
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pubmed:volume |
86
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
2365-8
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pubmed:dateRevised |
2009-11-18
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pubmed:meshHeading |
pubmed-meshheading:2784570-Cell Line,
pubmed-meshheading:2784570-Cell Survival,
pubmed-meshheading:2784570-Clone Cells,
pubmed-meshheading:2784570-Gene Expression Regulation,
pubmed-meshheading:2784570-Genes, Viral,
pubmed-meshheading:2784570-HIV-1,
pubmed-meshheading:2784570-Humans,
pubmed-meshheading:2784570-Promoter Regions, Genetic,
pubmed-meshheading:2784570-Recombinant Proteins,
pubmed-meshheading:2784570-T-Lymphocytes,
pubmed-meshheading:2784570-Transfection,
pubmed-meshheading:2784570-Tumor Necrosis Factor-alpha
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pubmed:year |
1989
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pubmed:articleTitle |
Tumor necrosis factor alpha induces expression of human immunodeficiency virus in a chronically infected T-cell clone.
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pubmed:affiliation |
Laboratory of Immunoregulation, National Institute of Allergy and Infectious Diseases, Bethesda, MD 20892.
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pubmed:publicationType |
Journal Article
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