Linked Life Data

278148

Source:http://linkedlifedata.com/resource/pubmed/id/278148

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
13
pubmed:dateCreated
1978-10-27
pubmed:abstractText
In several species of laboratory animals, the concurrent serum and tissue-cage fluid levels of several antibiotics after a single parenteral dose have markedly different profiles. New work has shown that these differences are mainly due to the relatively impermeable granulomatous sheath which develops around the implanted tissue chambers. The concentrations of an antibiotic in tissue-cage fluid are therefore not representative of its concentration in "interstitial fluid" or extravascular fluid in general. Tissue-cage levels are probably more representative of antibiotic levels to be found inside abscesses, in chronic disease situations, or relatively avascular sites in the body.
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:issn
0300-8878
pubmed:author
pubmed:issnType
Print
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
58-62
pubmed:dateRevised
2004-11-17
pubmed:meshHeading
pubmed:year
1978
pubmed:articleTitle
Implanted tissue-cages: a critical evaluation of their relevance in measuring tissue concentrations of antibiotics.
pubmed:publicationType
Journal Article