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rdf:type |
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lifeskim:mentions |
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pubmed:issue |
17
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pubmed:dateCreated |
1989-10-6
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pubmed:abstractText |
We reported that serum and tumor from a hypoglycemic patient with a fibrosarcoma contained insulin-like growth factor II (IGF-II), mostly in a large molecular form designated "big IGF-II." We now describe two additional patients with non-islet-cell tumor with hypoglycemia (NICTH) whose sera contained big IGF-II. Removal of the tumor eliminated most of the big IGF-II from the sera of two patients. Because specific IGF-binding proteins modify the bioactivity of IGFs, the sizes of the endogenous IGF-binding protein complexes were determined after neutral gel filtration through Saphadex G-200. Normally about 75% of IGFs are carried as a ternary complex of 150 kDa consisting of IGF, a growth hormone (GH)-dependent IGF-binding protein, and an acid-labile complexing component. The three patients with NICTH completely lacked the 150-kDa complex. IGF-II was present as a 60-kDa complex with variable contributions of smaller complexes. In the immediate postoperative period, a 110-kDa complex appeared rather than the expected 150-kDa complex. Abnormal IGF-II binding may be important in NICTH because the 150-kDa complexes cross the capillary membrane poorly. The smaller complexes present in our patients' sera would be expected to enter interstitial fluid readily, and a 4- to 5-fold increase in the fraction of IGFs reaching the target cells would result.
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pubmed:grant |
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pubmed:commentsCorrections |
http://linkedlifedata.com/resource/pubmed/commentcorrection/2771956-13493728,
http://linkedlifedata.com/resource/pubmed/commentcorrection/2771956-14422491,
http://linkedlifedata.com/resource/pubmed/commentcorrection/2771956-169287,
http://linkedlifedata.com/resource/pubmed/commentcorrection/2771956-2431001,
http://linkedlifedata.com/resource/pubmed/commentcorrection/2771956-2445506,
http://linkedlifedata.com/resource/pubmed/commentcorrection/2771956-2455727,
http://linkedlifedata.com/resource/pubmed/commentcorrection/2771956-2457595,
http://linkedlifedata.com/resource/pubmed/commentcorrection/2771956-2462321,
http://linkedlifedata.com/resource/pubmed/commentcorrection/2771956-2463906,
http://linkedlifedata.com/resource/pubmed/commentcorrection/2771956-2646313,
http://linkedlifedata.com/resource/pubmed/commentcorrection/2771956-2961563,
http://linkedlifedata.com/resource/pubmed/commentcorrection/2771956-2995817,
http://linkedlifedata.com/resource/pubmed/commentcorrection/2771956-2995818,
http://linkedlifedata.com/resource/pubmed/commentcorrection/2771956-3029761,
http://linkedlifedata.com/resource/pubmed/commentcorrection/2771956-3185662,
http://linkedlifedata.com/resource/pubmed/commentcorrection/2771956-3409868,
http://linkedlifedata.com/resource/pubmed/commentcorrection/2771956-3722172,
http://linkedlifedata.com/resource/pubmed/commentcorrection/2771956-3779638,
http://linkedlifedata.com/resource/pubmed/commentcorrection/2771956-4823931,
http://linkedlifedata.com/resource/pubmed/commentcorrection/2771956-6208022,
http://linkedlifedata.com/resource/pubmed/commentcorrection/2771956-6749876,
http://linkedlifedata.com/resource/pubmed/commentcorrection/2771956-6752163,
http://linkedlifedata.com/resource/pubmed/commentcorrection/2771956-6998997,
http://linkedlifedata.com/resource/pubmed/commentcorrection/2771956-7019228
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
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pubmed:status |
MEDLINE
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pubmed:month |
Sep
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pubmed:issn |
0027-8424
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pubmed:author |
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pubmed:issnType |
Print
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pubmed:volume |
86
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
6778-82
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pubmed:dateRevised |
2009-11-18
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pubmed:meshHeading |
pubmed-meshheading:2771956-Adult,
pubmed-meshheading:2771956-Aged,
pubmed-meshheading:2771956-Biological Markers,
pubmed-meshheading:2771956-Chromatography, Gel,
pubmed-meshheading:2771956-Female,
pubmed-meshheading:2771956-Fibrosarcoma,
pubmed-meshheading:2771956-Hemangiopericytoma,
pubmed-meshheading:2771956-Humans,
pubmed-meshheading:2771956-Hypoglycemia,
pubmed-meshheading:2771956-Insulin-Like Growth Factor I,
pubmed-meshheading:2771956-Insulin-Like Growth Factor II,
pubmed-meshheading:2771956-Leiomyosarcoma,
pubmed-meshheading:2771956-Male,
pubmed-meshheading:2771956-Protein Binding,
pubmed-meshheading:2771956-Somatomedins,
pubmed-meshheading:2771956-Thoracic Neoplasms
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pubmed:year |
1989
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pubmed:articleTitle |
Significance of abnormal serum binding of insulin-like growth factor II in the development of hypoglycemia in patients with non-islet-cell tumors.
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pubmed:affiliation |
Department of Medicine, Washington University School of Medicine, Saint Louis, MO 63110.
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pubmed:publicationType |
Journal Article,
Research Support, U.S. Gov't, P.H.S.,
Case Reports
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