| pubmed-article:2766813 | rdf:type | pubmed:Citation | lld:pubmed |
| pubmed-article:2766813 | lifeskim:mentions | umls-concept:C0024109 | lld:lifeskim |
| pubmed-article:2766813 | lifeskim:mentions | umls-concept:C0031307 | lld:lifeskim |
| pubmed-article:2766813 | lifeskim:mentions | umls-concept:C0812246 | lld:lifeskim |
| pubmed-article:2766813 | lifeskim:mentions | umls-concept:C0036205 | lld:lifeskim |
| pubmed-article:2766813 | lifeskim:mentions | umls-concept:C1456820 | lld:lifeskim |
| pubmed-article:2766813 | lifeskim:mentions | umls-concept:C0085732 | lld:lifeskim |
| pubmed-article:2766813 | lifeskim:mentions | umls-concept:C0205217 | lld:lifeskim |
| pubmed-article:2766813 | lifeskim:mentions | umls-concept:C1283071 | lld:lifeskim |
| pubmed-article:2766813 | lifeskim:mentions | umls-concept:C1513475 | lld:lifeskim |
| pubmed-article:2766813 | pubmed:issue | 3 | lld:pubmed |
| pubmed-article:2766813 | pubmed:dateCreated | 1989-9-29 | lld:pubmed |
| pubmed-article:2766813 | pubmed:abstractText | The TNF is a monokine with cytotoxic and tumor-necrosing activities; in addition, TNF may play a role in inflammatory processes. The present study evaluates spontaneous and LPS-mediated release of TNF by AMs and autologous peripheral BMs of normal subjects and patients with pulmonary sarcoidosis. A recently developed cytotoxicity assay, specific for detection of TNF activity, was applied. This study demonstrates that (1) unstimulated mononuclear phagocytes released low levels of TNF with no differences between groups; (2) when effector cells were stimulated with LPS, AMs from patients with active pulmonary sarcoidosis released more TNF than AMs recovered from normal subjects and from patients with inactive disease; (3) this increase was compartmentalized to the lungs, since comparisons of TNF production by LPS-stimulated BMs failed to show any difference between study groups. These results suggest that TNF might play a role in the pathogenesis of the alveolitis of pulmonary sarcoidosis. | lld:pubmed |
| pubmed-article:2766813 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:2766813 | pubmed:language | eng | lld:pubmed |
| pubmed-article:2766813 | pubmed:journal | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:2766813 | pubmed:citationSubset | AIM | lld:pubmed |
| pubmed-article:2766813 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:2766813 | pubmed:status | MEDLINE | lld:pubmed |
| pubmed-article:2766813 | pubmed:month | Sep | lld:pubmed |
| pubmed-article:2766813 | pubmed:issn | 0012-3692 | lld:pubmed |
| pubmed-article:2766813 | pubmed:author | pubmed-author:MelisMM | lld:pubmed |
| pubmed-article:2766813 | pubmed:author | pubmed-author:BonsignoreGG | lld:pubmed |
| pubmed-article:2766813 | pubmed:author | pubmed-author:BelliaVV | lld:pubmed |
| pubmed-article:2766813 | pubmed:author | pubmed-author:MerendinoAA | lld:pubmed |
| pubmed-article:2766813 | pubmed:author | pubmed-author:SpataforaMM | lld:pubmed |
| pubmed-article:2766813 | pubmed:author | pubmed-author:ChiapparaGG | lld:pubmed |
| pubmed-article:2766813 | pubmed:author | pubmed-author:GjomarkajMM | lld:pubmed |
| pubmed-article:2766813 | pubmed:issnType | Print | lld:pubmed |
| pubmed-article:2766813 | pubmed:volume | 96 | lld:pubmed |
| pubmed-article:2766813 | pubmed:owner | NLM | lld:pubmed |
| pubmed-article:2766813 | pubmed:authorsComplete | Y | lld:pubmed |
| pubmed-article:2766813 | pubmed:pagination | 542-9 | lld:pubmed |
| pubmed-article:2766813 | pubmed:dateRevised | 2004-11-17 | lld:pubmed |
| pubmed-article:2766813 | pubmed:meshHeading | pubmed-meshheading:2766813-... | lld:pubmed |
| pubmed-article:2766813 | pubmed:meshHeading | pubmed-meshheading:2766813-... | lld:pubmed |
| pubmed-article:2766813 | pubmed:meshHeading | pubmed-meshheading:2766813-... | lld:pubmed |
| pubmed-article:2766813 | pubmed:meshHeading | pubmed-meshheading:2766813-... | lld:pubmed |
| pubmed-article:2766813 | pubmed:meshHeading | pubmed-meshheading:2766813-... | lld:pubmed |
| pubmed-article:2766813 | pubmed:meshHeading | pubmed-meshheading:2766813-... | lld:pubmed |
| pubmed-article:2766813 | pubmed:meshHeading | pubmed-meshheading:2766813-... | lld:pubmed |
| pubmed-article:2766813 | pubmed:meshHeading | pubmed-meshheading:2766813-... | lld:pubmed |
| pubmed-article:2766813 | pubmed:meshHeading | pubmed-meshheading:2766813-... | lld:pubmed |
| pubmed-article:2766813 | pubmed:meshHeading | pubmed-meshheading:2766813-... | lld:pubmed |
| pubmed-article:2766813 | pubmed:meshHeading | pubmed-meshheading:2766813-... | lld:pubmed |
| pubmed-article:2766813 | pubmed:meshHeading | pubmed-meshheading:2766813-... | lld:pubmed |
| pubmed-article:2766813 | pubmed:meshHeading | pubmed-meshheading:2766813-... | lld:pubmed |
| pubmed-article:2766813 | pubmed:year | 1989 | lld:pubmed |
| pubmed-article:2766813 | pubmed:articleTitle | Lung compartmentalization of increased TNF releasing ability by mononuclear phagocytes in pulmonary sarcoidosis. | lld:pubmed |
| pubmed-article:2766813 | pubmed:affiliation | Consiglio Nazionale Delle Ricerche, Istituto di Fisiopatologia Respiratoria, Palermo, Italy. | lld:pubmed |
| pubmed-article:2766813 | pubmed:publicationType | Journal Article | lld:pubmed |
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| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:2766813 | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:2766813 | lld:pubmed |
