Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
3
pubmed:dateCreated
1989-9-21
pubmed:abstractText
We analyzed tissue and cells from a stationary and a rapidly growing hyperplastic callus from a patient with osteogenesis imperfecta (OI) type IV and compared the results with those of compact bone and skin fibroblasts of an age-matched control. Collagen and protein contents per cell were low in the callus tissues and collagen I and III were overmodified as evidenced by an elevated level of hydroxylysine. The degree of lysyl hydroxylation was highest in those regions that appeared most immature by histological examination. Lysyl hydroxylation approached normal levels in collagen from the stationary callus and from the center of the growing callus. Overmodification of collagen was not seen in compact bone or cell cultures (neither skin fibroblasts nor callus cells) from the patient. Elevation of hydroxylysine in collagen from OI patients is generally attributed to mutations that delay triple helix formation. Our observations suggest that the varying degree of collagen modifications may occur in consequence of regulatory mechanisms during bone development and tissue repair. These mechanisms may be defective in some patients with OI as seen in this case with hyperplastic callus formation.
pubmed:commentsCorrections
http://linkedlifedata.com/resource/pubmed/commentcorrection/2760218-1175627, http://linkedlifedata.com/resource/pubmed/commentcorrection/2760218-13084690, http://linkedlifedata.com/resource/pubmed/commentcorrection/2760218-13293190, http://linkedlifedata.com/resource/pubmed/commentcorrection/2760218-14907713, http://linkedlifedata.com/resource/pubmed/commentcorrection/2760218-2450280, http://linkedlifedata.com/resource/pubmed/commentcorrection/2760218-279454, http://linkedlifedata.com/resource/pubmed/commentcorrection/2760218-285932, http://linkedlifedata.com/resource/pubmed/commentcorrection/2760218-3107782, http://linkedlifedata.com/resource/pubmed/commentcorrection/2760218-3113698, http://linkedlifedata.com/resource/pubmed/commentcorrection/2760218-3341380, http://linkedlifedata.com/resource/pubmed/commentcorrection/2760218-3403536, http://linkedlifedata.com/resource/pubmed/commentcorrection/2760218-3706733, http://linkedlifedata.com/resource/pubmed/commentcorrection/2760218-3899103, http://linkedlifedata.com/resource/pubmed/commentcorrection/2760218-4022126, http://linkedlifedata.com/resource/pubmed/commentcorrection/2760218-4242678, http://linkedlifedata.com/resource/pubmed/commentcorrection/2760218-4276740, http://linkedlifedata.com/resource/pubmed/commentcorrection/2760218-458828, http://linkedlifedata.com/resource/pubmed/commentcorrection/2760218-4732855, http://linkedlifedata.com/resource/pubmed/commentcorrection/2760218-4835822, http://linkedlifedata.com/resource/pubmed/commentcorrection/2760218-5229569, http://linkedlifedata.com/resource/pubmed/commentcorrection/2760218-5277100, http://linkedlifedata.com/resource/pubmed/commentcorrection/2760218-6783428, http://linkedlifedata.com/resource/pubmed/commentcorrection/2760218-72122, http://linkedlifedata.com/resource/pubmed/commentcorrection/2760218-7430185, http://linkedlifedata.com/resource/pubmed/commentcorrection/2760218-793589
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
AIM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:month
Sep
pubmed:issn
0021-9738
pubmed:author
pubmed:issnType
Print
pubmed:volume
84
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
915-21
pubmed:dateRevised
2009-11-18
pubmed:meshHeading
pubmed:year
1989
pubmed:articleTitle
Biochemical analysis of callus tissue in osteogenesis imperfecta type IV. Evidence for transient overmodification in collagen types I and III.
pubmed:affiliation
Max Planck Institut für Biochemie, Martinsried, Federal Republic of Germany.
pubmed:publicationType
Journal Article, Case Reports, Research Support, Non-U.S. Gov't