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| Predicate | Object |
|---|---|
| rdf:type | |
| lifeskim:mentions | |
| pubmed:issue |
6
|
| pubmed:dateCreated |
1989-8-1
|
| pubmed:abstractText |
During the spontaneous differentiation (day 5 to day 15 of the culture) of Caco-2 cells, the sulfation of cell layer glycosaminoglycans increased, whereas protein kinase C activity was concomitantly redistributed from the membrane to the cytosol. The protein kinase C activators, 4 beta-phorbol 12 beta-myristate, 13 alpha-acetate and 1,2-dioctanoylglycerol inhibited glycosaminoglycan sulfation. By contrast, 4 alpha-phorbol 12, 13 didecanoate was ineffective. These results suggest that membrane-bound PKC may exert a modulatory effect on glycosaminoglycan sulfation, and this effect is gradually attenuated as Caco-2 cell differentiation progresses.
|
| pubmed:language |
eng
|
| pubmed:journal | |
| pubmed:citationSubset |
IM
|
| pubmed:chemical | |
| pubmed:status |
MEDLINE
|
| pubmed:month |
Jun
|
| pubmed:issn |
0014-4754
|
| pubmed:author | |
| pubmed:issnType |
Print
|
| pubmed:day |
15
|
| pubmed:volume |
45
|
| pubmed:owner |
NLM
|
| pubmed:authorsComplete |
Y
|
| pubmed:pagination |
588-91
|
| pubmed:dateRevised |
2007-11-15
|
| pubmed:meshHeading |
pubmed-meshheading:2737267-Cell Differentiation,
pubmed-meshheading:2737267-Cell Fractionation,
pubmed-meshheading:2737267-Colonic Neoplasms,
pubmed-meshheading:2737267-Glycosaminoglycans,
pubmed-meshheading:2737267-Humans,
pubmed-meshheading:2737267-Protein Kinase C,
pubmed-meshheading:2737267-Subcellular Fractions,
pubmed-meshheading:2737267-Sulfates,
pubmed-meshheading:2737267-Tumor Cells, Cultured
|
| pubmed:year |
1989
|
| pubmed:articleTitle |
Changes in glycosaminoglycan sulfation and protein kinase C subcellular distribution during differentiation of the human colon tumor cell line Caco-2.
|
| pubmed:affiliation |
Laboratoire de Biochimie, INSERM, Faculté de Médecine Saint-Antoine, Paris, France.
|
| pubmed:publicationType |
Journal Article,
Research Support, Non-U.S. Gov't
|