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rdf:type |
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lifeskim:mentions |
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pubmed:issue |
4
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pubmed:dateCreated |
1989-7-3
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pubmed:abstractText |
Recently a candidate gene for the primary testis-determining factor (TDF) encoding a zinc finger protein (ZFY) has been cloned from the human Y chromosome. A highly homologous X-linked copy has also been identified. Using this human sequence it is possible to identify two Y loci, an X and an autosomal locus in the mouse (Zfy-1, Zfy-2, Zfx and Zfa, respectively). Suprisingly ZFY is more homologous to the mouse X and autosomal sequences than it is to either of the Y-linked loci. Both Zfy-1 and Zfy-2 are present in the Sxr region of the Y but Zfy-2 is absent in the Sxr deletion variant Sxrb (or Sxr") suggesting it is not necessary for male determination. Extensive backcross analyses map Zfa to mouse chromosome 10 and Zfx to a 5-cM interval between anonymous X probe MDXS120 and the tabby locus (Ta). We also show that the mouse androgen receptor locus (m-AR) believed to underlie the testicular feminization mutation (Tfm) shows complete linkage to Zfx. Comparative mapping indicates that in man these genes lie in separate conserved DNA segments.
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pubmed:commentsCorrections |
http://linkedlifedata.com/resource/pubmed/commentcorrection/2721933-13632697,
http://linkedlifedata.com/resource/pubmed/commentcorrection/2721933-2899541,
http://linkedlifedata.com/resource/pubmed/commentcorrection/2721933-2903046,
http://linkedlifedata.com/resource/pubmed/commentcorrection/2721933-2907799,
http://linkedlifedata.com/resource/pubmed/commentcorrection/2721933-2983233,
http://linkedlifedata.com/resource/pubmed/commentcorrection/2721933-3037543,
http://linkedlifedata.com/resource/pubmed/commentcorrection/2721933-3070850,
http://linkedlifedata.com/resource/pubmed/commentcorrection/2721933-3353726,
http://linkedlifedata.com/resource/pubmed/commentcorrection/2721933-3353727,
http://linkedlifedata.com/resource/pubmed/commentcorrection/2721933-3413106,
http://linkedlifedata.com/resource/pubmed/commentcorrection/2721933-3690661,
http://linkedlifedata.com/resource/pubmed/commentcorrection/2721933-3863136,
http://linkedlifedata.com/resource/pubmed/commentcorrection/2721933-5452809,
http://linkedlifedata.com/resource/pubmed/commentcorrection/2721933-6320193,
http://linkedlifedata.com/resource/pubmed/commentcorrection/2721933-6326095,
http://linkedlifedata.com/resource/pubmed/commentcorrection/2721933-6542174,
http://linkedlifedata.com/resource/pubmed/commentcorrection/2721933-6729462
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
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pubmed:status |
MEDLINE
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pubmed:month |
Apr
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pubmed:issn |
0016-6731
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pubmed:author |
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pubmed:issnType |
Print
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pubmed:volume |
121
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
803-9
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pubmed:dateRevised |
2010-11-18
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pubmed:meshHeading |
pubmed-meshheading:2721933-Animals,
pubmed-meshheading:2721933-Base Sequence,
pubmed-meshheading:2721933-Blotting, Southern,
pubmed-meshheading:2721933-Chromosome Mapping,
pubmed-meshheading:2721933-DNA-Binding Proteins,
pubmed-meshheading:2721933-Female,
pubmed-meshheading:2721933-Genetic Linkage,
pubmed-meshheading:2721933-Gonadal Steroid Hormones,
pubmed-meshheading:2721933-Humans,
pubmed-meshheading:2721933-Kruppel-Like Transcription Factors,
pubmed-meshheading:2721933-Male,
pubmed-meshheading:2721933-Mice,
pubmed-meshheading:2721933-Mice, Inbred C57BL,
pubmed-meshheading:2721933-Recombination, Genetic,
pubmed-meshheading:2721933-Sequence Homology, Nucleic Acid,
pubmed-meshheading:2721933-Transcription Factors,
pubmed-meshheading:2721933-X Chromosome,
pubmed-meshheading:2721933-Y Chromosome
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pubmed:year |
1989
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pubmed:articleTitle |
Localization of murine X and autosomal sequences homologous to the human Y located testis-determining region.
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pubmed:affiliation |
Unité d'Immunogénétique Humaine, Institut Pasteur, Paris, France.
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pubmed:publicationType |
Journal Article,
Comparative Study,
Research Support, Non-U.S. Gov't
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