| pubmed-article:269451 | rdf:type | pubmed:Citation | lld:pubmed |
| pubmed-article:269451 | lifeskim:mentions | umls-concept:C0034693 | lld:lifeskim |
| pubmed-article:269451 | lifeskim:mentions | umls-concept:C0439660 | lld:lifeskim |
| pubmed-article:269451 | lifeskim:mentions | umls-concept:C0011848 | lld:lifeskim |
| pubmed-article:269451 | lifeskim:mentions | umls-concept:C0027900 | lld:lifeskim |
| pubmed-article:269451 | lifeskim:mentions | umls-concept:C0205307 | lld:lifeskim |
| pubmed-article:269451 | lifeskim:mentions | umls-concept:C0220781 | lld:lifeskim |
| pubmed-article:269451 | pubmed:issue | 9 | lld:pubmed |
| pubmed-article:269451 | pubmed:dateCreated | 1977-11-30 | lld:pubmed |
| pubmed-article:269451 | pubmed:abstractText | When [35S]cysteine was injected adjacent to the supraoptic nucleus (SON) in rats, it was rapidly incorporated into proteins in the SON. The [35S]cysteine-labeled proteins extracted from the SON were separated by isoelectric focusing on polyacrylamide gels. Twenty minutes after the injection of [35S]cysteine, two major labeled peaks (pI = 5.4 and 6.1) were found in the SON of normal rats; Brattleboro rats had only one major labeled peak (pI = 5.4). One hour after the injection, four major radioactive peaks were found in the SON of normal animals (pI = 5.1, 5.4, 5.6, and 6.1). Animals with diabetes insipidus had only two major labeled proteins (pI = 5.1 AND 5.4). Twenty-four hours after normal rats were injected with [35S]cysteine, all of the labeled peaks described above, except for the one with pI = 5.1, had decreased markedly in size and a small amount of labeled protein with pI about 4.8 was present in the SON. After 24 hr the posterior pituitary of normal animals contained two [35S]cysteine-labeled proteins with pI = 4.6 AND 4.8. The pituitaries of Brattleboro rats had only the pI = 4.6 labeled protein. These pulse-chase data, with data we have presented elsewhere, indicate that the vasopressin- and oxytocin-neurophysins are synthesized as parts of separate precursors (pI = 6.1 and 5.4, respectively). These precursors are converted into at least two intermediates (pI = 5.6 and 5.1) which, in turn, yield the vasopressin-neurophysin (pI = 4.8) and the oxytocin-neurophysin (pI = 4.6). | lld:pubmed |
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| pubmed-article:269451 | pubmed:language | eng | lld:pubmed |
| pubmed-article:269451 | pubmed:journal | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:269451 | pubmed:citationSubset | IM | lld:pubmed |
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| pubmed-article:269451 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:269451 | pubmed:status | MEDLINE | lld:pubmed |
| pubmed-article:269451 | pubmed:month | Sep | lld:pubmed |
| pubmed-article:269451 | pubmed:issn | 0027-8424 | lld:pubmed |
| pubmed-article:269451 | pubmed:author | pubmed-author:BrownsteinM... | lld:pubmed |
| pubmed-article:269451 | pubmed:author | pubmed-author:GainerHH | lld:pubmed |
| pubmed-article:269451 | pubmed:issnType | Print | lld:pubmed |
| pubmed-article:269451 | pubmed:volume | 74 | lld:pubmed |
| pubmed-article:269451 | pubmed:owner | NLM | lld:pubmed |
| pubmed-article:269451 | pubmed:authorsComplete | Y | lld:pubmed |
| pubmed-article:269451 | pubmed:pagination | 4046-9 | lld:pubmed |
| pubmed-article:269451 | pubmed:dateRevised | 2009-11-18 | lld:pubmed |
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| pubmed-article:269451 | pubmed:meshHeading | pubmed-meshheading:269451-N... | lld:pubmed |
| pubmed-article:269451 | pubmed:year | 1977 | lld:pubmed |
| pubmed-article:269451 | pubmed:articleTitle | Neurophysin biosynthesis in normal rats and in rats with hereditary diabetes insipidus. | lld:pubmed |
| pubmed-article:269451 | pubmed:publicationType | Journal Article | lld:pubmed |
| pubmed-article:269451 | pubmed:publicationType | Comparative Study | lld:pubmed |
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