Switch to
Predicate | Object |
---|---|
rdf:type | |
lifeskim:mentions | |
pubmed:issue |
4
|
pubmed:dateCreated |
1989-11-17
|
pubmed:abstractText |
Two babies with congenital difficulties in swallowing and breathing are presented and contrasted. Both were associated with maternal polyhydramnios, but one was due to medullary infarction and the other to a malformation ("neurocristopathy"). In the former case, isolated tenth and twelfth cranial nerve palsies provided the clue as to the correct etiology, whereas the latter baby had dyscoordination of swallowing and breathing with sleep apnea ("Ondine's curse"). It is somewhat ironic that the case without a difficult delivery had the infarct, probably prenatal in onset, whereas the one with a difficult delivery had the congenital malformation. Neural crest cells are known to migrate widely and to develop greatly different functions, but the fact that their central associations of neural tube origin may also be affected has not previously been emphasized in the etiopathogenesis of the congenital malformation. A variety of syndromes with combinations of many defects may be seen in which too many or too few cells are formed, with more or less serious consequences especially for the respiratory and gastrointestinal systems.
|
pubmed:grant | |
pubmed:commentsCorrections | |
pubmed:language |
eng
|
pubmed:journal | |
pubmed:citationSubset |
IM
|
pubmed:status |
MEDLINE
|
pubmed:month |
Oct
|
pubmed:issn |
0883-0738
|
pubmed:author | |
pubmed:issnType |
Print
|
pubmed:volume |
4
|
pubmed:owner |
NLM
|
pubmed:authorsComplete |
Y
|
pubmed:pagination |
299-306
|
pubmed:dateRevised |
2007-11-14
|
pubmed:meshHeading |
pubmed-meshheading:2677115-Breech Presentation,
pubmed-meshheading:2677115-Cerebral Infarction,
pubmed-meshheading:2677115-Cranial Nerve Diseases,
pubmed-meshheading:2677115-Deglutition Disorders,
pubmed-meshheading:2677115-Female,
pubmed-meshheading:2677115-Humans,
pubmed-meshheading:2677115-Infant, Newborn,
pubmed-meshheading:2677115-Medulla Oblongata,
pubmed-meshheading:2677115-Polyhydramnios,
pubmed-meshheading:2677115-Pregnancy,
pubmed-meshheading:2677115-Respiratory Distress Syndrome, Newborn,
pubmed-meshheading:2677115-Risk Factors,
pubmed-meshheading:2677115-Sleep Apnea Syndromes,
pubmed-meshheading:2677115-Vertebral Artery
|
pubmed:year |
1989
|
pubmed:articleTitle |
Congenital difficulties with swallowing and breathing associated with maternal polyhydramnios: neurocristopathy or medullary infarction?
|
pubmed:affiliation |
Department of Pathology, University of Washington School of Medicine, Seattle 98195.
|
pubmed:publicationType |
Journal Article,
Research Support, U.S. Gov't, P.H.S.,
Review,
Case Reports
|