|
rdf:type |
|
|
lifeskim:mentions |
|
|
pubmed:issue |
7
|
|
pubmed:dateCreated |
1989-9-12
|
|
pubmed:abstractText |
The analysis of gene expression in cytotoxic T cells by in situ hybridization of serial liver and brain sections from mice infected with lymphocytic choriomeningitis virus (LCMV) and immunostaining with T cell marker- and virus-specific antibodies revealed a close histological association of infiltrating lymphocytes expressing the perforin and granzyme A genes with virally infected cells. Maximal frequency of perforin and granzyme A mRNA-containing cells on liver sections preceded by about 2 days maximal LCMV-specific cytotoxicity of the lymphoid liver infiltrating cells. These results are most consistent with an involvement of perforin and granzyme A in cell-mediated cytotoxicity in vivo.
|
|
pubmed:grant |
|
|
pubmed:language |
eng
|
|
pubmed:journal |
|
|
pubmed:citationSubset |
IM
|
|
pubmed:chemical |
|
|
pubmed:status |
MEDLINE
|
|
pubmed:month |
Jul
|
|
pubmed:issn |
0014-2980
|
|
pubmed:author |
|
|
pubmed:issnType |
Print
|
|
pubmed:volume |
19
|
|
pubmed:owner |
NLM
|
|
pubmed:authorsComplete |
Y
|
|
pubmed:pagination |
1253-9
|
|
pubmed:dateRevised |
2007-11-15
|
|
pubmed:meshHeading |
pubmed-meshheading:2668013-Animals,
pubmed-meshheading:2668013-Brain,
pubmed-meshheading:2668013-Gene Expression Regulation,
pubmed-meshheading:2668013-Granzymes,
pubmed-meshheading:2668013-Hepatitis, Viral, Animal,
pubmed-meshheading:2668013-Immunoenzyme Techniques,
pubmed-meshheading:2668013-Liver,
pubmed-meshheading:2668013-Lymphocytic Choriomeningitis,
pubmed-meshheading:2668013-Membrane Glycoproteins,
pubmed-meshheading:2668013-Membrane Proteins,
pubmed-meshheading:2668013-Mice,
pubmed-meshheading:2668013-Nucleic Acid Hybridization,
pubmed-meshheading:2668013-Perforin,
pubmed-meshheading:2668013-Pore Forming Cytotoxic Proteins,
pubmed-meshheading:2668013-RNA, Messenger,
pubmed-meshheading:2668013-RNA Probes,
pubmed-meshheading:2668013-Serine Endopeptidases,
pubmed-meshheading:2668013-T-Lymphocytes, Cytotoxic,
pubmed-meshheading:2668013-Time Factors
|
|
pubmed:year |
1989
|
|
pubmed:articleTitle |
Detection of perforin and granzyme A mRNA in infiltrating cells during infection of mice with lymphocytic choriomeningitis virus.
|
|
pubmed:affiliation |
Department of Pathology, University of Bern.
|
|
pubmed:publicationType |
Journal Article,
Research Support, U.S. Gov't, P.H.S.,
Research Support, Non-U.S. Gov't
|
