Source:http://linkedlifedata.com/resource/umls/id/C0070410
MSH: A calcium-dependent pore-forming protein synthesized in cytolytic LYMPHOCYTES and sequestered in secretory granules. Upon immunological reaction between a cytolytic lymphocyte and a target cell, perforin is released at the plasma membrane and polymerizes into transmembrane tubules (forming pores) which lead to death of a target cell.,NCI: Perforin-1 (555 aa, ~61 kDa) is encoded by the human PRF1 gene. This protein is involved in the mediation of cytolysis of infected cells.