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rdf:type |
|
|
lifeskim:mentions |
|
|
pubmed:issue |
6227
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|
pubmed:dateCreated |
1989-8-2
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|
pubmed:abstractText |
Actively transcribing eukaryotic RNA polymerase II is highly phosphorylated on its repetitive carboxyl-terminal domain. We have isolated a protein kinase that phosphorylates serine residues in this repetitive domain. A component of this kinase is cdc2, the product of a cell-cycle control gene previously shown to be a component of M-phase-promoting factor and M-phase-specific histone H1 kinase. This observation suggests a role for the cdc2 protein kinase in transcriptional regulation.
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pubmed:language |
eng
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|
pubmed:journal |
|
|
pubmed:citationSubset |
IM
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|
pubmed:chemical |
|
|
pubmed:status |
MEDLINE
|
|
pubmed:month |
Jun
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|
pubmed:issn |
0028-0836
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|
pubmed:author |
|
|
pubmed:issnType |
Print
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|
pubmed:day |
29
|
|
pubmed:volume |
339
|
|
pubmed:owner |
NLM
|
|
pubmed:authorsComplete |
Y
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pubmed:pagination |
679-84
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pubmed:dateRevised |
2009-11-19
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pubmed:meshHeading |
pubmed-meshheading:2662013-Amino Acid Sequence,
pubmed-meshheading:2662013-Animals,
pubmed-meshheading:2662013-CDC2 Protein Kinase,
pubmed-meshheading:2662013-Cell Cycle,
pubmed-meshheading:2662013-Gene Expression Regulation,
pubmed-meshheading:2662013-Humans,
pubmed-meshheading:2662013-Mice,
pubmed-meshheading:2662013-Molecular Sequence Data,
pubmed-meshheading:2662013-Phosphoproteins,
pubmed-meshheading:2662013-Phosphorylation,
pubmed-meshheading:2662013-Protein Kinases,
pubmed-meshheading:2662013-RNA Polymerase II,
pubmed-meshheading:2662013-Species Specificity,
pubmed-meshheading:2662013-Transcription, Genetic
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|
pubmed:year |
1989
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|
pubmed:articleTitle |
Phosphorylation of RNA polymerase by the murine homologue of the cell-cycle control protein cdc2.
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|
pubmed:affiliation |
Howard Hughes Medical Institute, Johns Hopkins School of Medicine, Baltimore, Maryland 21205.
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pubmed:publicationType |
Journal Article,
Comparative Study,
Research Support, U.S. Gov't, P.H.S.,
Research Support, Non-U.S. Gov't
|
