Linked Life Data

2658521

Source:http://linkedlifedata.com/resource/pubmed/id/2658521

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
6
pubmed:dateCreated
1989-7-5
pubmed:abstractText
With the use of the enzyme-linked immunosorbent assay technique and indirect immunofluorescence, we determined the frequency of antibodies to laminin (a noncollagenous protein of basement membrane) and their influence on endomyocardial laminin distribution in 132 patients suffering from dilated cardiomyopathy and myocarditis. Seventy-eight percent of 91 patients with dilated cardiomyopathy and 73% of 41 patients with myocarditis exhibited significantly elevated anti-laminin antibody levels compared with 68 apparently healthy persons. A positive correlation was found between hemodynamic data and irregular myocardial immunofluorescence laminin staining patterns in dilated cardiomyopathy and myocarditis. With regard to recent studies, these data suggest that antibodies to laminin in dilated cardiomyopathy and myocarditis enhance clusters of cell-surface laminin, inducing an alteration of the cytoskeleton, which may account for functional abnormalities in dilated cardiomyopathy and myocarditis. Considering the fact that optical microscopy is unable to resolve sarcolemmal structures proper from the basement membranes, the high prevalence of laminin autoantibodies in dilated cardiomyopathy and myocarditis raises doubts as to the diagnostic value of direct immunofluorescence findings.
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
AIM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:month
Jun
pubmed:issn
0002-8703
pubmed:author
pubmed:issnType
Print
pubmed:volume
117
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
1303-9
pubmed:dateRevised
2006-11-15
pubmed:meshHeading
pubmed:year
1989
pubmed:articleTitle
Laminin distribution and autoantibodies to laminin in dilated cardiomyopathy and myocarditis.
pubmed:affiliation
Department of Internal Medicine, Klinikum Grosshadern, University of Munich.
pubmed:publicationType
Journal Article, Research Support, Non-U.S. Gov't